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Biological Safety of Fish (Tilapia) Collagen


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Title: Biological Safety of Fish (Tilapia) Collagen
Authors: Yamamoto, Kohei / Igawa, Kazunari / Sugimoto, Kouji / Yoshizawa, Yuu / Yanagiguchi, Kajiro / Ikeda, Takeshi / Yamada, Shizuka / Hayashi, Yoshihiko
Issue Date: 7-Apr-2014
Publisher: Hindawi Publishing Corporation
Citation: BioMed Research International, 2014, 630757; 2014
Abstract: Marine collagen derived from fish scales, skin, and bone has been widely investigated for application as a scaffold and carrier due to its bioactive properties, including excellent biocompatibility, low antigenicity, and high biodegradability and cell growth potential. Fish type I collagen is an effective material as a biodegradable scaffold or spacer replicating the natural extracellular matrix, which serves to spatially organize cells, providing them with environmental signals and directing site-specific cellular regulation. This study was conducted to confirm the safety of fish (tilapia) atelocollagen for use in clinical application. We performed in vitro and in vivo biological studies of medical materials to investigate the safety of fish collagen. The extract of fish collagen gel was examined to clarify its sterility. All present sterility tests concerning bacteria and viruses (including endotoxin) yielded negative results, and all evaluations of cell toxicity, sensitization, chromosomal aberrations, intracutaneous reactions, acute systemic toxicity, pyrogenic reactions, and hemolysis were negative according to the criteria of the ISO and the Ministry of Health, Labour and Welfare of Japan. The present study demonstrated that atelocollagen prepared from tilapia is a promising biomaterial for use as a scaffold in regenerative medicine.
URI: http://hdl.handle.net/10069/34498
ISSN: 23146133
DOI: 10.1155/2014/630757
Rights: © 2014 Kohei Yamamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34498

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