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Toll-like receptor system and endometriosis

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Title: Toll-like receptor system and endometriosis
Authors: Khan, Khaleque Newaz / Kitajima, Michio / Fujishita, Akira / Nakashima, Masahiro / Masuzaki, Hideaki
Issue Date: Aug-2013
Publisher: 日本産科婦人科学会 / Japan Society of Obstetrics and Gynecology
Citation: The Journal of Obstetrics and Gynaecology Research, 39(8), pp.1281-1292; 2013
Abstract: Endometriosis is an estrogen-dependent chronic inflammatory condition associated with variable degrees of pelvic pain and infertility. Studies have showed that the growth and progression of endometriosis continue even in ovariectomized animals. This indicates that besides ovarian steroid hormones, the growth of endometriosis can be regulated by the innate immune system in the pelvic environment. As a component of innate immune system, increased infiltration of macrophages has been described in the intact tissue and peritoneal fluid of women with endometriosis. Different immune cells and dendritic cells express Toll-like receptors (TLR) and exhibit functional activity in response to microbial products. In this review article, we discuss the role of the TLR system in endometrium and endometriosis and outline the involvement of cytokines/endotoxin in causing adverse reproductive outcome. In the first part of this review article, the fundamentals of innate immune system, functional characteristics of TLR and signaling pathways of TLR4 are discussed for easy understanding by the readers.
Keywords: bacterial endotoxin / endometriosis / endometrium / infertility / innate immunity / Toll-like receptors
URI: http://hdl.handle.net/10069/34520
ISSN: 13418076
DOI: 10.1111/jog.12117
Rights: © 2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology / The definitive version is available at Wiley Online Library , www.wileyonlinelibrary.com.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34520

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