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Expression of alpha smooth muscle actin in living donor liver transplant recipients

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Title: Expression of alpha smooth muscle actin in living donor liver transplant recipients
Authors: Hirabaru, Masataka / Mochizuki, Kyoko / Takatsuki, Mitsuhisa / Soyama, Akihiko / Kosaka, Taiichiro / Kuroki, Tamotsu / Shimokawa, Isao / Eguchi, Susumu
Issue Date: 14-Jun-2014
Publisher: WJG Press
Citation: World Journal of Gastroenterology, 20(22), pp.7067-7074; 2014
Abstract: Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosuppressant medication and liver fibrosis. The study enrolled two pediatric patients who underwent living donor liver transplantation and ceased immunosuppressant therapy. The number of α-SMA-positive cells in the specimens obtained by liver biopsy from these two patients showed a three-fold increase compared with the number from four transplanted pediatric patients who were continuing immunosuppressant therapy. In addition, the α-SMA-positive area evaluated using the Win- RooF image processing software program continued to increase over time in three adult transplanted patients with liver fibrosis, and the α-SMA-positive area was increasing even during the pre-fibrotic stage in these adult cases, according to a retrospective review. Therefore, α-SMA could be a useful marker for the detection of early stage fibrosis.
Keywords: Alpha smooth muscle actin / Hepatic stellate cells / Immunosuppressant therapy / Liver fibrosis / Living donor liver transplantation
URI: http://hdl.handle.net/10069/34553
ISSN: 10079327
DOI: 10.3748/wjg.v20.i22.7067
Rights: ©1995-2014 Baishideng Publishing Group Inc. All rights reserved. Articles published by this open-access journal are distributed under the terms of the Creative Commons Attribution-Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34553

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