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Adenine-and-Uridine-rich element RNA-binding factor 1 (AUF1) as an additional marker in human gliomas


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タイトル: Adenine-and-Uridine-rich element RNA-binding factor 1 (AUF1) as an additional marker in human gliomas
著者: Haraguchi, Wataru / Matsuo, Takayuki / Yoshida, Koichi / Nagata, Izumi
発行日: 2014年 7月
出版者: Nagasaki University School of Medicine / 長崎大学医学部
引用: Acta medica Nagasakiensia, 59(1), pp.7-11; 2014
抄録: AUF1 is one of Adenine-and-Uridine-rich elements binding protein which regulates the mRNA stability of many genes related to growth regulation, cytokines, and cell cycle-regulatory genes. There was no report about the expression of AUF1 in gliomas. Sections of formalin-fixed, paraffin-embedded tissues from 71 gliomas were stained immunohistochemically using a polyclonal antibody against the adenine-and-uridine-rich element RNA-Binding factor 1 (AUF1) oncoprotein. Positive staining, which is known to correlate with gene amplification, was not associated with patients' sex, age, Karnofsky performance status scores (KPS), tumor size, Bcl-2 expression, or longer overall survival. However, positive staining was negatively correlated with the MIB-1 labeling index, while it was positively correlated with the lower grade group of WHO classification. Expression of the AUF1 oncoprotein appears to be an important additional indicator in human gliomas.
キーワード: glioma / AUF1 / Adenine-and-Uridine rich element
URI: http://hdl.handle.net/10069/34695
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 59, No. 1

引用URI : http://hdl.handle.net/10069/34695

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