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Video-assisted thoracic surgery attenuates perioperative oxidative stress response in lung cancer patients: a preliminary study


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タイトル: Video-assisted thoracic surgery attenuates perioperative oxidative stress response in lung cancer patients: a preliminary study
著者: Miyazaki, Takuro / Takagi, Katsunori / Mine, Mariko / Yamasaki, Naoya / Tsuchiya, Tomoshi / Matsumoto, Keitaro / Hatachi, Go / Izumino, Hiroo / Doi, Ryoichiro / Machino, Ryusuke / Nagayasu, Takeshi
発行日: 2014年 7月
出版者: Nagasaki University School of Medicine / 長崎大学医学部
引用: Acta medica Nagasakiensia, 59(1), pp.19-25; 2014
抄録: Objectives: Reactive oxygen species (ROS) function as key metabolites that can impair biological processes. The aim of this preliminary study was to assess the perioperative oxidative changes in lung cancer surgery. Methods: We measured the levels of blood hydroperoxides, a type of ROS, as an index of oxidative injury to cellular components, as well as the plasma ferric-reducing ability as an index of total antioxidant potential in 32 lung cancer patients. Hydroperoxides were measured by the levels of diacron reactive oxygen metabolites (d-ROMs). The antioxidant potential was determined by the biological antioxidant potential (BAP), which represents the levels of endogenous antioxidant enzymes. Results: Lung cancer patients had slightly affected oxidative stress before surgery. The d-ROM and BAP levels after surgery and were significantly decreased than before surgery (p< 0.001) and the levels recovered preoperatively at third postoperative day. The d-ROM level in video-assisted surgery group (n=17) was significantly decreased than those in thoracotomy group (n=15) at third and seventh post-operative day (p < 0.001, and < 0.02). Conclusions: Lung cancer patients had already exposed oxidative stress before surgery and surgical intervention also generates large amounts of ROS. Video-assisted thoracic surgery can reduce the ROS compared to the standard thoractomy.
キーワード: lung cancer / oxidative stress / video-assisted thoracic surgery
URI: http://hdl.handle.net/10069/34697
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 59, No. 1

引用URI : http://hdl.handle.net/10069/34697

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