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Autoimmune pulmonary alveolar proteinosis co-existing with breast cancer: a case report

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Title: Autoimmune pulmonary alveolar proteinosis co-existing with breast cancer: a case report
Authors: Sawai, Toyomitsu / Umeyama, Yasuhiro / Yoshioka, Sumako / Matsuo, Nobuko / Suyama, Naofumi / Kohno, Shigeru
Issue Date: 19-Aug-2014
Publisher: BioMed Central
Citation: Journal of Medical Case Reports, 8(1), 279; 2014
Abstract: Introduction. Pulmonary alveolar proteinosis is a rare pulmonary disease characterized by excessive alveolar accumulation of surfactant due to defective alveolar clearance by macrophages. There are only a few published case reports of pulmonary alveolar proteinosis occurring in association with solid cancers. To the best of our knowledge, there are no previously reported cases of pulmonary alveolar proteinosis associated with breast cancer. Case presentation. A 48-year-old Asian woman, a nonsmoker, presented to our institution with a right breast mass. Biopsy examination of the lesion revealed scirrhous carcinoma. A chest computed tomography scan for metastases showed abnormal shadows in both upper lung fields. As a result of flexible fiberscopic bronchoscopy, this patient was diagnosed as having pulmonary alveolar proteinosis. This case was categorized as autoimmune pulmonary alveolar proteinosis due to the positive anti-granulocyte-macrophage colony-stimulating factor antibody. Pulmonary alveolar proteinosis decreased gradually after mastectomy. Conclusions: The present case involved the coincident occurrence of autoimmune pulmonary alveolar proteinosis with breast cancer; breast cancer may be a factor during pulmonary alveolar proteinosis development.
Keywords: Breast cancer / Co-existing / Pulmonary alveolar proteinosis
URI: http://hdl.handle.net/10069/34826
ISSN: 17521947
DOI: 10.1186/1752-1947-8-279
Rights: © 2014 SAWAI et al.; licensee BioMed Central Ltd. / This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34826

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