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A Japanese Patient with Löfgren’s Syndrome with an HLA-DR12 Allele and Review of Literature on Japanese Patients

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Title: A Japanese Patient with Löfgren’s Syndrome with an HLA-DR12 Allele and Review of Literature on Japanese Patients
Authors: Ishimatsu, Yuji / Koyama, Hanako / Tomonaga, Masaomi / Harada, Tatsuhiko / Nakashima, Shota / Hara, Atsuko / Hara, Shintaro / Kakugawa, Tomoyuki / Sakamoto, Noriho / Hayashi, Tomayoshi / Kohno, Shigeru
Issue Date: 30-Sep-2014
Publisher: 東北ジャーナル刊行会 / Tohoku University Medical Press
Citation: The Tohoku Journal of Experimental Medicine, 234(2), pp.137-141; 2014
Abstract: Sarcoidosis is a granulomatous disorder of unknown etiology, with several clinical manifestations. Löfgren’s syndrome is an acute type of sarcoidosis, characterized by the triad of arthritis, erythema nodosum, and bilateral hilar lymphadenopathy (BHL), which spontaneously resolve within about 2 years. Löfgren’s syndrome is common among young white women from Nordic countries and Ireland, but it is very rare in Japan. Because the incidence of Löfgren’s syndrome varies according to race, most studies on Löfgren’s syndrome, including HLA typing, have been reported in Western countries. Indeed, HLA-DR3 has been reported to be associated with Löfgren’s syndrome in Western countries, although the association between HLA typing and Japanese Löfgren’s syndrome remains unclear. Here we present a Japanese patient with Löfgren’s syndrome. A 34-year-old female patient was hospitalized with arthritis and erythema nodosum. Chest computed tomography revealed mediastinal and BHL. Endobronchial ultrasound-guided transbronchial needle aspiration showed non-caseating epithelioid cell granulomas. Löfgren’s syndrome was thus diagnosed. Her ankle arthralgia and bilateral ankle swelling recovered without steroid treatment within two months, and the BHL almost completely diminished one year after admission. Her HLA genotype contains DR12. We also reviewed the literature on 11 Japanese patients with Löfgren’s syndrome, showing that HLA-DR12 is present in fve out of nine patients (55.6%). The relevant data were unavailable in the remaining three patients. Importantly, only 5.4% of registered donors in the Japan Marrow Donor Program are positive for this allele. We suggest the potential link between HLA-DR12 and the pathogenesis of Löfgren’s syndrome in Japanese patients.
Keywords: HLA typing / Human leukocyte antigen / Japan / Löfgren’s syndrome / Sarcoidosis
URI: http://hdl.handle.net/10069/34909
ISSN: 00408727
DOI: 10.1620/tjem.234.137
Rights: © 2014 Tohoku University Medical Press
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34909

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