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Hemophagocytic Syndrome and Inflammatory Myopathy with Abundant Macrophages in a Patient with Adult-onset Still's Disease


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Title: Hemophagocytic Syndrome and Inflammatory Myopathy with Abundant Macrophages in a Patient with Adult-onset Still's Disease
Authors: Umeda, Masataka / Origuchi, Tomoki / Fujikawa, Keita / Koga, Tomohiro / Mizokami, Akinari / Nakashima, Yoshikazu / Suzuki, Takahisa / Okada, Akitomo / Kawashiri, Shin-ya / Ichinose, Kunihiro / Tamai, Mami / Yamasaki, Satoshi / Nakamura, Hideki / Kawakami, Atsushi / Eguchi, Katsumi
Issue Date: 15-Oct-2014
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 53(20), pp.2385-2389; 2014
Abstract: We herein describe a 71-year-old woman with adult-onset Still's disease (AOSD) who developed fever, myalgia, and pancytopenia. The bone marrow aspiration and muscle biopsy revealed hemophagocytic syndrome (HPS) and inflammatory myopathy with abundant macrophages (IMAM). Immunostained specimens were positive for expression of retinoic acid-inducible gene-I (RIG-I), which recognizes viral RNA in infiltrated mononuclear cells as well as muscle tissues. These findings suggest that RIG-I may be involved in induction of HPS and IMAM in AOSD.
Keywords: Adult-onset Still's disease / Hemophagocytic syndrome / Inflammatory myopathy with abundant / macrophages
URI: http://hdl.handle.net/10069/34939
ISSN: 09182918
DOI: 10.2169/internalmedicine.53.1081
Rights: © 2014 by The Japanese Society of Internal Medicine
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34939

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