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Lack of a surface layer in Tannerella forsythia mutants deficient in the type IX secretion system


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Title: Lack of a surface layer in Tannerella forsythia mutants deficient in the type IX secretion system
Authors: Narita, Yuka / Sato, Keiko / Yukitake, Hideharu / Shoji, Mikio / Nakane, Daisuke / Nagano, Keiji / Yoshimura, Fuminobu / Naito, Mariko / Nakayama, Koji
Issue Date: 1-Oct-2014
Publisher: Society for General Microbiology
Citation: Microbiology, 160, pp.2295-2303; 2014
Abstract: Tannerella forsythia, a Gram-negative anaerobic bacterium, is an important pathogen in periodontal disease. This bacterium possesses genes encoding all known components of the type IX secretion system (T9SS). T. forsythia mutants deficient in genes orthologous to the T9SS-encoding genes porK, porT and sov were constructed. All porK, porT and sov single mutants lacked the surface layer (S-layer) and expressed less-glycosylated versions of the S-layer glycoproteins TfsA and TfsB. In addition, these mutants exhibited decreased haemagglutination and increased biofilm formation. Comparison of the proteins secreted by the porK and WT strains revealed that the secretion of several proteins containing C-terminal domain (CTD)-like sequences is dependent on the porK gene. These results indicate that the T9SS is functional in T. forsythia and contributes to the translocation of CTD proteins to the cell surface or into the extracellular milieu.
URI: http://hdl.handle.net/10069/34941
ISSN: 13500872
DOI: 10.1099/mic.0.080192-0
Rights: © 2014 Society for General Microbiology / This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34941

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