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Infectious cerebral thromboembolism in a patient with lung cancer during long-term administration of gefitinib: a case report


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タイトル: Infectious cerebral thromboembolism in a patient with lung cancer during long-term administration of gefitinib: a case report
著者: Shimada, Midori / Fukuda, Minoru / Onn, Yumi / Abe, Noriko / Irie, Junji / Kitazaki, Takeshi / Hashiguchi, Kohji / Fukuda, Masaaki / Nakamura, Yoichi / Suyama, Naofumi / Ashizawa, Kazuto / Kohno, Shigeru
発行日: 2014年12月
出版者: Nagasaki University School of Medicine / 長崎大学医学部
引用: Acta medica Nagasakiensia, 59(2), pp.67-71; 2014
抄録: Introduction  Gefitinib is a molecularly targeted drug for oral administration, a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). It is effective for patients with lung cancer who have EGFR mutation and enables long-term survival of patients with advanced disease. Case presentation  An 84-year-old Asian female with lung cancer (adenocarcinoma, cT4N3M1b stage IV PUL BRA OSS ADR) was treated by gefitinib for two years. The primary tumor was markedly reduced, and bone metastasis had almost disappeared. However, the patient became unconsciousness with general edema and died two days after falling unconsciousness. In the autopsy, it was diagnosed as infectious cerebral thromboembolism due to infectious endocarditis. The cause of death was cardiac tamponade. Conclusions  While long-term survival can be expected in patients with advanced lung cancer by molecular-targeted agents, cautious management is warranted for complications, the same as for the primary disease.
キーワード: lung cancer / infectious endocarditis / gefitinib
URI: http://hdl.handle.net/10069/34981
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 59, No. 2

引用URI : http://hdl.handle.net/10069/34981

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