DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > School of Medicine > Bulletin > Acta Medica Nagasakiensia > Volume 59, No. 2 >

Infectious cerebral thromboembolism in a patient with lung cancer during long-term administration of gefitinib: a case report


File Description SizeFormat
ActMed59_67.pdf669.94 kBAdobe PDFView/Open

Title: Infectious cerebral thromboembolism in a patient with lung cancer during long-term administration of gefitinib: a case report
Authors: Shimada, Midori / Fukuda, Minoru / Onn, Yumi / Abe, Noriko / Irie, Junji / Kitazaki, Takeshi / Hashiguchi, Kohji / Fukuda, Masaaki / Nakamura, Yoichi / Suyama, Naofumi / Ashizawa, Kazuto / Kohno, Shigeru
Issue Date: Dec-2014
Publisher: Nagasaki University School of Medicine / 長崎大学医学部
Citation: Acta medica Nagasakiensia, 59(2), pp.67-71; 2014
Abstract: Introduction  Gefitinib is a molecularly targeted drug for oral administration, a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). It is effective for patients with lung cancer who have EGFR mutation and enables long-term survival of patients with advanced disease. Case presentation  An 84-year-old Asian female with lung cancer (adenocarcinoma, cT4N3M1b stage IV PUL BRA OSS ADR) was treated by gefitinib for two years. The primary tumor was markedly reduced, and bone metastasis had almost disappeared. However, the patient became unconsciousness with general edema and died two days after falling unconsciousness. In the autopsy, it was diagnosed as infectious cerebral thromboembolism due to infectious endocarditis. The cause of death was cardiac tamponade. Conclusions  While long-term survival can be expected in patients with advanced lung cancer by molecular-targeted agents, cautious management is warranted for complications, the same as for the primary disease.
Keywords: lung cancer / infectious endocarditis / gefitinib
URI: http://hdl.handle.net/10069/34981
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 59, No. 2

Citable URI : http://hdl.handle.net/10069/34981

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace