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ヒト培養細胞由来と酵母由来遺伝子組換えB型肝炎ワクチンの効果の比較


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Title: ヒト培養細胞由来と酵母由来遺伝子組換えB型肝炎ワクチンの効果の比較
Other Titles: Comparison of efficacy of human cell-derived and yeast-derived recombinant hepatitis B vaccines
Authors: 田代, 隆良 / 田中, 千明 / 疋田, 桂子 / 緒方, 優衣 / 西崎, 仁美 / 田代, 将人 / 石松, 祐二 / 泉川, 公一
Authors (alternative): Tashiro, Takayoshi / Tanaka, Chiaki / Hikita, Keiko / Ogata, Yui / Nishizaki, Hitomi / Tashiro, Masato / Ishimatsu, Yuji / Izumikawa, Koichi
Issue Date: Jan-2015
Publisher: 長崎大学大学院医歯薬学総合研究科保健学専攻 / Master Course of Health Sciences Graduate School of Biomedical Sciences Nagasaki University
Citation: 保健学研究, 27, pp.21-27; 2015
Abstract: 2000 ~ 2013年度に入学した長崎大学看護学生1,000名のHBs抗原とHBs抗体を検査した.HBs抗原陽性率は0.10%(2000 ~ 2004年0.27%,2005 ~ 2013年0.0%),HBs抗体陽性率は1.80%(2000 ~ 2004年1.08%,2005 ~ 2013年2.22%)だった.HBs抗原・HBs抗体とも陰性だった970名に対しヒト培養細胞由来遺伝子組換え沈降 B 型肝炎ワクチン「明乳」(Mワクチン)または酵母由来遺伝子組換え沈降 B 型肝炎ワクチン「ビームゲン」(B ワクチン)を接種した.ワクチン接種後のHBs抗体獲得率は,Mワクチン接種者(n=563)98.0%,B ワクチン接種者(n=407)99.0%と変わりないが,HBs抗体価中央値は,2120.0mIU/mL,313.0mIU/mLとMワクチン接種者が有意差に高かった.HBs抗体価は経年的に低下し,ワクチン接種後の抗体価が低い者はより早期に陰性となった.すなわち,HBs抗体陽性持続期間はMワクチン接種者が B 接種者より長かった. / A total of 1,000 nursing students of Nagasaki University School of Health Sciences were examined for serum HBsAg and anti-HBs at their first year between 2000 and 2013. The prevalence of HBsAg was 0.10%; 0.27% in 2000-2004 and 0.0% in 2005-2013. The prevalence of anti-HBs was 1.80%; 1.08 % in 2000-2004 and 2.22% in 2005-2013. A total of 970 students who were negative for HBsAg and anti-HBs received a primary series of hepatitis B vaccinations with human cell-derived recombinant vaccines (Meinyu) or yeast-derived recombinant vaccines (Bimmugen). Subsequently, 98.0% by Meinyu (n=563)and 99.0% by Bimmugen( n=407) acquired anti-HBs titers over 10 mIU/mL. The median titers of anti-HBs in Meinyu recipients( 2120.0 mIU/mL) were significantly higher than those in Bimmugen recipients (313.0 mIU/mL). The anti-HBs titers were declined with time following vaccination, and the decline seemed to depend on the titer originally obtained. Thus, Meinyu recipients may have more persistence of anti-HBs titers over 10 mIU/mL than Bimmugen recipients.
Keywords: B 型肝炎ワクチン / HBs抗体 / HBs抗原 / 看護学生 / Hepatitis B vaccine / Anti-HBs / HBsAg / Nursing students
URI: http://hdl.handle.net/10069/35041
ISSN: 18814441
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 27

Citable URI : http://hdl.handle.net/10069/35041

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