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Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect


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Title: Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect
Authors: Kamohara, Ryotaro / Yamaza, Haruyoshi / Tsuchiya, Tomoshi / Komatsu, Toshimitsu / Park, Seongjoon / Hayashi, Hiroko / Chiba, Takuya / Mori, Ryoichi / Otabe, Shuichi / Yamada, Kentaro / Nagayasu, Takeshi / Shimokawa, Isao
Issue Date: Apr-2015
Publisher: Elsevier Inc.
Citation: Experimental Gerontology, 64, pp.46-54; 2015
Abstract: Adiponectin (Adipoq), a peptide hormone secreted from the white adipose tissue, may play a role in the anti-aging and/or anti-tumor effects of calorie restriction (CR). We analyzed metabolic traits in Adipoq gene-overexpressing mice fed ad libitum with a regular diet (RD) or a high-fat diet (HFD), or fed 30% CR of RD initiated at 12. weeks of age. Adipoq-RD and -HFD mice at 6. months of age showed reduced blood glucose and insulin concentrations, and thus increased insulin sensitivity, compared with WT mice fed a RD or a HFD. In the epididymal white adipose tissue in Adipoq mice, senescence-like changes such as upregulation of p53 protein and of biomarkers of inflammation, Cd68 and Ccl2 mRNA, were ameliorated compared with WT-RD and WT-HFD mouse tissues. Resistance to stress induced by lipopolysaccharide was also strengthened in Adipoq mice compared with WT mice. These metabolic changes and stress resistance were also noted in the WT-CR mice, suggesting that Adipoq plays a part in the effect of CR. In contrast, in an allograft tumor growth model, tumor growth was not inhibited in Adipoq mice. The present findings suggest that Adipoq plays a part in the anti-aging, but not in the anti-tumor, effects of CR.
Keywords: Adiponectin / Calorie restriction / ER stress / Insulin / P53 / Tumor growth
URI: http://hdl.handle.net/10069/35172
ISSN: 05315565
DOI: 10.1016/j.exger.2015.02.011
Rights: © 2015 Elsevier Inc. / NOTICE: this is the author’s version of a work that was accepted for publication in Experimental Gerontology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Experimental Gerontology, 64, (2015)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35172

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