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Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases

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Title: Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases
Authors: Ichinose, Kunihiro / Arima, Kazuhiko / Ushigusa, Takeshi / Nishino, Ayako / Nakashima, Yoshikazu / Suzuki, Takahisa / Horai, Yoshiro / Nakajima, Hideki / Kawashiri, Shin-ya / Iwamoto, Naoki / Tamai, Mami / Nakamura, Hideki / Origuchi, Tomoki / Motomura, Masakatsu / Kawakami, Atsushi
Issue Date: Apr-2015
Publisher: Academic Press Inc.
Citation: Clinical Immunology, 157(2), pp.114-120; 2015
Abstract: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in SLE. Although the mechanism of NPSLE remains unclear, cytokines and chemokines are considered to be involved in their pathogenesis. Here we used Bio-Plex Pro assays to examine 27 types of cytokines and chemokines in the cerebrospinal fluid (CSF) of 32 NPSLE patients. We used the CSF of 20 patients with multiple sclerosis (MS) and 22 patients with neuromyelitis optica (NMO) as a disease control group. Fourteen of 27 cytokines/chemokines were significantly higher in the NPSLE patients compared to the MS/NMO patients. We could identify six "minimum predictive markers" by using a weighted-voting algorithm that could distinguish NPSLE from MS and NMO: interleukin (IL)-17, IL-2, interferon (IFN)-γ, IL-5, basic fibroblast growth factor (FGF)-basic and IL-15. The determination of various types of CSF cytokine profiles may contribute to the diagnosis of NPSLE and may help elucidate the mechanisms underlying this disease.
Keywords: Cerebrospinal fluid / Cytokine profiles / Neuropsychiatric systemic lupus erythematosus / Weighted-voting algorithm
URI: http://hdl.handle.net/10069/35260
ISSN: 15216616
DOI: 10.1016/j.clim.2015.01.010
Rights: © 2015 Elsevier Inc. / NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical Immunology, 157, 2, (2015)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35260

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