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FOXC2 Expression is Associated with Tumor Proliferation and Invasion Potential in Oral Tongue Squamous Cell Carcinoma


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Title: FOXC2 Expression is Associated with Tumor Proliferation and Invasion Potential in Oral Tongue Squamous Cell Carcinoma
Authors: Imayama, Naomi / Yamada, Shin-ichi / Yanamoto, Souichi / Naruse, Tomofumi / Matsushita, Yuki / Takahashi, Hidenori / Seki, Sachiko / Fujita, Shuichi / Ikeda, Tohru / Umeda, Masahiro
Issue Date: Jul-2015
Publisher: Springer Netherlands
Citation: Pathology & Oncology Research, 21(3), pp.783-791; 2015
Abstract: Forkhead box protein C2 (FOXC2) is a gene encoding a transcription factor that controls the generation of mesodermal tissue including vascular and lymphatic tissues. FOXC2 has previously been associated with EMT and tumor angiogenesis in various cancers. Moreover, a relationship between the expression of FOXC2 and poor prognosis has been reported in various cancers. We herein examined the clinicopathological significance of FOXC2 in oral tongue squamous cell carcinoma (OTSCC) and attempted to clarify the function of FOXC2 in OTSCC cell lines in vitro. The overexpression of FOXC2 was more frequent in cancers with higher grades according to the pattern of invasion (grade 4 vs. 1–3; p < 0.05). A correlation was observed between the expression of FOXC2 and that of VEGF-A and -C (VEGF-A; p < 0.05, VEGF-C; p < 0.001). The high-FOXC2 expression group had a significantly poorer prognosis than that of the low-expression group (p < 0.001). Multivariate analysis indicated that the overexpression of FOXC2 may also be an independent prognostic factor, similar to N classification (N0 vs 1/2; p < 0.05), stage classification (stage I/II vs III/IV; p < 0.05), pattern of invasion (grade 1-3vs 4; p < 0.05), local recurrence (local recurrence (+) vs (−); p < 0.01), and the overexpression of FOXC2 (FOXC2 overexpression (−) vs.(+); p < 0.05). In the OTSCC cell line analysis, the expression of FOXC2 was also associated with proliferation and invasion potential. These results strongly suggest that the overexpression of FOXC2 may be a potent predictor of survival in OTSCC patients.
Keywords: FOXC2 / Invasion / Metastasis / Oral tongue squamous cell carcinoma / Proliferation
URI: http://hdl.handle.net/10069/35464
ISSN: 12194956
DOI: 10.1007/s12253-014-9891-6
Relational Links: http://hdl.handle.net/10069/35627
Rights: © Aranyi Lajos Foundation 2015 / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35464

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