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Characteristic patterns of relapse after allogeneic hematopoietic SCT for adult T-cell leukemia–lymphoma: a comparative study of recurrent lesions after transplantation and chemotherapy by the Nagasaki Transplant Group


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Title: Characteristic patterns of relapse after allogeneic hematopoietic SCT for adult T-cell leukemia–lymphoma: a comparative study of recurrent lesions after transplantation and chemotherapy by the Nagasaki Transplant Group
Authors: Itonaga, Hidehiro / Sawayama, Yasushi / Taguchi, Jun / Honda, Sumihisa / Taniguchi, Hiroaki / Makiyama, Junnya / Matsuo, Emi / Sato, Shinya / Ando, Koji / Imanishi, Daisuke / Imaizumi, Yoshitaka / Yoshida, Shinichiro / Hata, Tomoko / Moriuchi, Yukiyoshi / Fukushima, Takuya / Miyazaki, Yasushi
Issue Date: 4-Apr-2015
Publisher: Nature Publishing Group
Citation: Bone Marrow Transplantation, 50(4), pp.585-591; 2015
Abstract: Allogeneic hematopoietic SCT (allo-SCT) is a promising therapy that may provide long-term durable remission for adult T-cell leukemia-lymphoma (ATL) patients; however, the incidence of relapse associated with ATL remains high. To determine the clinical features of these patients at relapse, we retrospectively analyzed tumor lesions in 30 or 49 patients who relapsed following allo-SCT or chemotherapy (CHT), respectively, at three institutions in Nagasaki prefecture between 1997 and 2011. A multivariate analysis revealed that the development of abnormal lymphocytes in the peripheral blood of patients at relapse was less frequent after allo-SCT than after CHT (P<0.001). Furthermore, relapse with a new lesion only in the absence of the primary lesion was more frequent in allo-SCT (P=0.014). Lesions were more frequently observed in the central nervous systems of patients who relapsed with new lesions only (P=0.005). Thus, the clinical manifestation of relapsed ATL was slightly complex, especially in post-transplant patients. Our results emphasized the need to develop adoptive modalities for early and accurate diagnoses of relapsed ATL.
Keywords: adult T-cell leukemia-lymphoma / transplantation / relapse / tumor lesion
URI: http://hdl.handle.net/10069/35605
ISSN: 02683369
DOI: 10.1038/bmt.2014.308
Rights: © 2015 Macmillan Publishers Limited.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35605

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