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Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models

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Title: Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models
Authors: Muraoka, Izumi / Takatsuki, Mitsuhisa / Soyama, Akihiko / Yamaguchi, Izumi / Tanaka, Shiro / Tanaka, Takayuki / Kinoshita, Ayaka / Hara, Takanobu / Kuroki, Tamotsu / Eguchi, Susumu
Issue Date: Sep-2015
Publisher: Elsevier Ltd
Citation: Annals of Medicine and Surgery, 4(3), pp.211-214; 2015
Abstract: Introduction: To clarify the influence of Dai-Kenchu-To (DKT) on portal blood flow (PBF), PBF was continuously measured with Doppler ultrasound. Methods: Normal liver rats were divided into a DKT 90 mg/kg, DKT 270 mg/kg administered group, and control, while cirrhotic liver rats were divided into a DKT-LC 90 mg/kg administered group and Control-LC. The PBF was measured after the administration of either DKT or water for 60 min by laser Doppler flowmetry system. Results: The PBF in the DKT 90 increased approximately 10 min after DKT was administrated, and elevated levels were maintained for approximately 10 min. A comparison of the increase in PBF by the calculating the area under the curve (AUC) revealed that flow was significantly higher in the DKT 90 compared to either the control or the DKT 270 (p < 0.05). The cirrhotic liver group showed stable PBF in both the DKT-LC and Control-LC. The AUC, revealed no significant difference between the DKT-LC and Control-LC. Discussion: DKT induced an increase in PBF in normal livers; however, its effects were insufficient to increase PBF in the cirrhotic livers. No increase in the portal blood flow in the cirrhotic liver rats was probably the result of the cirrhotic liver, which had fibrotic change, and, therefore, may not have had sufficient compliance to accept the increasing blood flow volume from the intestinal tract. Conclusion: We suggested DKT has the potential to protect the liver by increasing PBF when the liver has either normal or mild to moderate dysfunction.
Keywords: Dai-kenchu-to (DKT) / Herbal medicine / Liver cirrhosis / Liver regeneration / Portal blood flow
URI: http://hdl.handle.net/10069/35660
ISSN: 20490801
DOI: 10.1016/j.amsu.2015.05.008
Rights: © 2015 Published by Elsevier Ltd on behalf of IJS Publishing Group Limited. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35660

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