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Poly(l-lactic acid)-modified silica stationary phase for reversed-phase and hydrophilic interaction liquid chromatography


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Title: Poly(l-lactic acid)-modified silica stationary phase for reversed-phase and hydrophilic interaction liquid chromatography
Authors: Ohyama, Kaname / Takasago, Shizuka / Kishikawa, Naoya / Kuroda, Naotaka
Issue Date: Mar-2015
Publisher: Wiley-VCH Verlag
Citation: Journal of Separation Science, 38(5), pp.720-723; 2015
Abstract: Poly(L-lactic acid) is a linear aliphatic thermoplastic polyester that can be produced from renewable resources. A poly(L-lactic acid)-modified silica stationary phase was newly prepared by amide bond reaction between amino groups on aminopropyl silica and carboxylic acid groups at the end of the poly(L-lactic acid) chain. The poly(L-lactic acid)-silica column was characterized in reversed-phase liquid chromatography and hydrophilic interaction liquid chromatography with the use of different mobile phase compositions. The poly(L-lactic acid)-silica column was found to work in both modes, and the retention of test compounds depending on acetonitrile content exhibited "U-shaped" curves, which was an indicator of reversed-phase liquid chromatography/hydrophilic interaction liquid chromatography mixed-mode retention behavior. In addition, carbonyl groups included into the poly(L-lactic acid) backbone work as an electron-accepting group toward a polycyclic aromatic hydrocarbon and provide π- π interactions.
Keywords: Hydrophilic interaction chromatography / Mixed-mode chromatography / Poly(L-lactic acid) / Reversed-phase chromatography
URI: http://hdl.handle.net/10069/35719
ISSN: 16159306
DOI: 10.1002/jssc.201401243
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. / This is the accepted version of the following article: Journal of Separation Science, 38(5), pp.720-723; 2015, which has been published in final form at http://dx.doi.org/10.1002/jssc.201401243
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35719

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