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Comparison of Pulmonary Involvement Between Patients Expressing Anti-PL-7 and Anti-Jo-1 Antibodies

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Title: Comparison of Pulmonary Involvement Between Patients Expressing Anti-PL-7 and Anti-Jo-1 Antibodies
Authors: Tomonaga, Masaomi / Sakamoto, Noriho / Ishimatsu, Yuji / Kakugawa, Tomoyuki / Harada, Tatsuhiko / Nakashima, Shota / Hara, Atsuko / Hara, Shintaro / Horai, Yoshihiro / Kawakami, Atsushi / Mukae, Hiroshi / Kohno, Shigeru
Issue Date: Feb-2015
Publisher: Springer New York
Citation: Lung, 193(1), pp.79-83; 2015
Abstract: Anti-PL-7 is an anti-tRNA synthetase antibody, and interstitial lung disease (ILD) is the most frequent complication of anti-PL-7-associated antisynthetase syndrome. However, the features of ILD have not been fully elucidated. The present study retrospectively compares 7 and 15 patients who were positive for anti-PL-7 and anti-Jo-1 antibodies, respectively. The features of ILD did not significantly differ between the two groups, but the ratio of lymphocytes in bronchoalveolar lavage fluid was higher in the Jo-1 than in the PL-7 group. High-resolution computed tomography revealed nonspecific interstitial pneumonia in all patients in the PL-7 group and organizing pneumonia in four of the 15 patients in the Jo-1 group. These findings suggest that pulmonary complications slightly differ between patients expressing anti-PL-7 and anti-Jo-1 antibodies. Further studies are required to clarify the features of ILD associated with PL-7.
Keywords: Antisynthetase syndrome / Dermatomyositis / Interstitial lung disease / Polymyositis
URI: http://hdl.handle.net/10069/35786
ISSN: 03412040
DOI: 10.1007/s00408-014-9665-7
Rights: © 2014, Springer Science+Business Media New York. / The final publication is available at link.springer.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35786

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