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On-going malaria transmission in The Gambia despite high coverage of control interventions: a nationwide cross-sectional survey

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Title: On-going malaria transmission in The Gambia despite high coverage of control interventions: a nationwide cross-sectional survey
Authors: Mwesigwa, Julia / Okebe, Joseph / Affara, Muna / Di Tanna, Gian Luca / Nwakanma, Davis / Janha, Omar / Opondo, Kevin / Peeters Grietens, Koen / Achan, Jane / D’Alessandro, Umberto
Issue Date: 14-Aug-2015
Publisher: BioMed Central Ltd.
Citation: Malaria Journal, 14, 314; 2015
Abstract: Background: As indicators of burden of malaria have substantially decreased in The Gambia, reaching a pre-elimination status may be attainable. Achieving this goal requires in-depth understanding of the current burden of Plasmodium falciparum infection. Methods: A nationwide cross-sectional survey was conducted in 2012 to determine the prevalence of P. falciparum infection, and to describe its heterogeneity and associated risk factors. Finger-prick blood samples were collected for microscopy, species-specific PCR and haemoglobin measurement. Results: A total of 9,094 participants were included and median age was 11.9 years (IQR 5, 28). Overall prevalence of P. falciparum was 16.01 % with marked heterogeneity between sites (4.32-36.75 %) and within villages in each site (1.63-49.13 %). Across all sites, 51.17 % (745/1,456) of infections were asymptomatic and 35.61 % (448/1,258) were sub-microscopic. The odds of P. falciparum infection were higher in older children; 5-15 years (OR = 1.90; 95 % CI 1.60-2.26), adults (OR = 1.48; 95 % CI 1.24-1.78) and participants with moderate anaemia (OR = 1.62; 95 % CI 1.32-1.99). Conclusions: The current malaria control interventions are not sufficient to interrupt transmission in The Gambia as malaria prevalence is still relatively high in the eastern part of the country. New interventions aiming at interrupting transmission are needed and should be urgently evaluated.
Keywords: Asymptomatic parasitaemia / Heterogeneity / Malaria transmission / The Gambia
URI: http://hdl.handle.net/10069/35803
DOI: 10.1186/s12936-015-0829-6
Rights: © 2015 Mwesigwa et al. / This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35803

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