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Immunohistochemical study of vascular endothelial growth factor‑C/vascular endothelial growth factor receptor‑3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis


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Title: Immunohistochemical study of vascular endothelial growth factor‑C/vascular endothelial growth factor receptor‑3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis
Authors: Naruse, Tomofumi / Yanamoto, Souichi / Yamada, Shin‑Ichi / Takahashi, Hidenori / Matsushita, Yuki / Imayama, Naomi / Ikeda, Hisazumi / Shiraishi, Takeshi / Fujita, Shuichi / Ikeda, Tohru / Asahina, Izumi / Umeda, Masahiro
Issue Date: Oct-2015
Publisher: Spandidos Publications
Citation: Oncology Letters, 10(4), pp.2027-2034; 2015
Abstract: The aim of the present study was to elucidate the associations between the expression of the vascular endothelial growth factor-C (VEGF-C)/VEGF receptor-3 (VEGFR-3) axis and lymphangiogenesis, regional lymph node metastasis and clinicopathological factors in oral tongue squamous cell carcinoma (OTSCC) using immunohistochemistry. The expression of VEGF-C, VEGFR-3 and podoplanin was immunohistochemically evaluated in specimens obtained from 65 patients with OTSCC (T1-2, N0) who had undergone radical surgery alone. The associations between the expression of VEGF-C, VEGFR-3 and podoplanin, and lymphangiogenesis, regional lymph node metastasis and clinocopathological factors were determined by immunohistochemical analysis. VEGF-C, VEGFR-3 and combined VEGF-C/VEGFR-3 expression was significantly higher in cases with regional recurrence compared with those without lymph node involvement (P<0.001). As regards lymphangiogenesis, a significant correlation was observed between podoplanin expression and VEGF-C, VEGFR-3 and combined VEGF-C/VEGFR-3 expression (P<0.001). Therefore, lymphangiogenesis in the peritumoral stroma was associated with lymph node metastasis. However, podoplanin expression did not exhibit a significant correlation with the progression of lymph node metastasis. The results of the present study suggest that the VEGF-C/VEGFR-3 axis may be associated with lymph node metastasis through lymphangiogenesis. Determining the VEGF-C/VEGFR-3 expression status may help predict which patients will develop regional recurrence and provide novel targets for therapies to suppress lymph node metastasis in the treatment of OTSCC.
Keywords: Podoplanin / Regional recurrence / Tongue cancer / Vascular endothelial growth factor receptor-3 / Vascular endothelial growth factor-C
URI: http://hdl.handle.net/10069/35833
ISSN: 17921074
DOI: 10.3892/ol.2015.3565
Rights: © Naruse et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/35833

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