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Assessment of lower urinary tract function in children with Down syndrome


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Title: Assessment of lower urinary tract function in children with Down syndrome
Other Titles: ダウン症候群児における下部尿路機能の評価
Authors: 北村, 温子
Authors (alternative): Kitamura, Atsuko
Issue Date: 1-Oct-2014
Publisher: 日本小児科学会
Citation: Nagasaki University (長崎大学), 博士(医学) (2014-10-01)
Abstract: Background Despite the fact that functional lower urinary tract symptoms are common among people with Down syndrome (DS), their voiding function has not been studied precisely. Our goal was to assess the lower urinary tract functions in DS. Methods Fifty-five DS children aged 5-15 years old and 35 age-matched control children were evaluated by ultrasonography and uroflowmetry. Results Eleven (20%) DS children had no uresiesthesia, 21 (38%) were urinated under guidance, nine (16%) urinated fewer than three times a day, two (4%) urinated more than 10 times a day, three (5%) used diapers, and 26 (47%) had urinary incontinence. Seven (13%), 15 (27%), and 10 (18%) DS children had weak, prolonged and intermittent urination, respectively, and seven (13%) had urination with straining. In contrast, none of the control subjects had urinary problems. In the uroflowmetrical analysis, 10 (18%), 20 (37%), 11 (20%) and five (9%) DS children showed "bell-shaped," "plateau," "staccato" and "interrupted" patterns, respectively; the remaining nine (16%) could not be analyzed. In contrast, 21 (60%), one (3%), four (11%), three (9%) and two (6%) control subjects showed bell-shaped, tower-shaped, plateau, staccato and interrupted patterns, respectively; the remaining four (11%) could not be analyzed. Residual urine was demonstrated in four (7%) DS children and one (3%) control child. Conclusions Lower urinary tract symptoms and abnormal uroflowmetry findings, which can lead to further progressive renal and urinary disorders, are common in DS children. Therefore, lower urinary tract functions should be assessed at the life-long regular medical check-ups for subjects with DS.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第723号 学位授与年月日:平成26年10月1日 / Author: Atsuko Kitamura, Tatsuro Kondoh, Mitsuru Noguchi, Teppei Hatada, Shohei Tohbu, Ken-ichi Mori, Manabu Matsuo, Ichiro Kunitsugu, Hiroshi Kanetake, Hiroyuki Moriuchi / Citation: Pediatrics International, 56(6), pp.902-908; 2014
Keywords: Down syndrome / lower urinary tract symptoms / uroflowmetry
URI: http://hdl.handle.net/10069/35852
ISSN: 13288067
DOI: 10.1111/ped.12367
Relational Links: http://hdl.handle.net/10069/35359
Rights: © 2014 The Authors. Pediatrics International published by Wiley Publishing Asia Pty Ltd on behalf of Japan Pediatric Society.
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/35852

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