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Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice


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Title: Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice
Authors: Yamanaka, Hitoki / Nakanishi, Tai / Takagi, Toshikazu / Ohsawa, Makiko / Kubo, Noriaki / Yamamoto, Naoto / Takemoto, Takahira / Ohsawa, Kazutaka
Issue Date: 23-Oct-2015
Publisher: 日本実験動物学会 / Japanese Association for Laboratory Animal Science
Citation: Experimental Animals, 64(4), pp.375-382; 2015
Abstract: Helicobacter sp. MIT 01-6451 has been detected in SPF mice kept in Japan. To characterize strain MIT 01-6451, its infection route during fetal and neonatal life and effects on pregnancy were investigated using immunocompetent and immunodeficient mouse strains (BALB/c, C57BL/6, and SCID). MIT 01-6451 was detected in the uterus, vagina, and mammary glands of 50% of infected SCID mice, whereas these tissues were all negative in immunocompetent mice. No fetal infections with MIT 01-6451 were detected at 16–18 days after pregnancy in any mouse strain. In newborn mice, MIT 01-6451 was detected in intestinal tissue of C57BL/6 and SCID mice at 9–11 days after birth, but not in BALB/c mice. The IgA and IgG titers to MIT 01-6451 in sera of C57BL/6 female mice were significantly lower than those of BALB/c mice. Although no significant differences in the number of newborns per litter were observed between MIT 01-6451-infected and MIT 01-6451-free dams, the birth rate was lower in infected SCID mice than in control SCID mice. The present results indicated that MIT 01-6451 infects newborn mice after birth rather than by vertical transmission to the fetus via the placenta and that MIT 01-6451 infection shows opportunistically negative effects on the birth rate. In addition, the maternal immune response may affect infection of newborn mice with MIT 01-6451 through breast milk.
Keywords: Helicobacter sp. MIT 01-6451 / Laboratory mice / Reproductive organ / Vertical transmission
URI: http://hdl.handle.net/10069/36040
ISSN: 13411357
DOI: 10.1538/expanim.15-0034
Rights: ©2015 Japanese Association for Laboratory Animal Science.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/36040

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