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Reevaluation for clinical manifestations of HTLV-I-seropositive patients with Sjögren’s syndrome

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Title: Reevaluation for clinical manifestations of HTLV-I-seropositive patients with Sjögren’s syndrome
Authors: Nakamura, Hideki / Shimizu, Toshimasa / Takagi, Yukinori / Takahashi, Yoshiko / Horai, Yoshiro / Nakashima, Yoshikazu / Sato, Shuntaro / Shiraishi, Hirokazu / Nakamura, Tatsufumi / Fukuoka, Junya / Nakamura, Takashi / Kawakami, Atsushi
Issue Date: 4-Nov-2015
Publisher: BioMed Central
Citation: BMC Musculoskeletal Disorders, 16, 335; 2015
Abstract: Background: The aim of the study was to reassess the prevalence and characteristics of human T lymphotropic virus type I (HTLV-I)-associated Sjögren's syndrome (SS) and SS in HTLV-I-associated myelopathy (HAM) based on the American European Consensus Group (AECG) criteria in HTLV-I endemic area, Nagasaki prefecture. Methods: The 349 patients who underwent a minor salivary gland biopsy (MSGB) for suspected SS were retrospectively classified by AECG classification criteria and divided with or without anti-HTLV-I antibody. Results: The HTLV-I data-available 294 patients were investigated. One hundred-seventy patients were classified as SS and 26.5 % were HTLV-I-seropositive. We have included 26 patients with HTLV-I-associated myelopathy (HAM) and 38.5 % were classified as having SS. The prevalences of ANA and anti-SS-A/Ro antibody of HAM + SS were significantly low compared to the HTLV-I asymptomatic carriers (AC) with SS and the HTLV-I-seronegative SS patients, although lacrimal dysfunction tended to be high in HAM + SS and significantly high in AC + SS patients compared with the patients with HTLV-I-seronegative SS. The focus scores of MSGB in the HAM + SS patients were similar to those of the AC + SS patients and the HTLV-I-seronegative patients with SS. Among the MSGB-positive patients, there was a low prevalence of ANA in the HAM + SS patients. Similar results were obtained in case of anti-SS-A/Ro or SS-B/La antibody. Conclusion: In HTLV-I endemic area, high prevalence of anti-HTLV-I antibody among SS as well as the characteristics of HAM + SS and AC + SS was still determined by AECG classification criteria.
Keywords: AECG criteria / HTLV-I / Minor salivary gland biopsy / Sjögren's syndrome
URI: http://hdl.handle.net/10069/36072
DOI: 10.1186/s12891-015-0773-1
Rights: © Nakamura et al. 2015 / This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/36072

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