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Risk factors for death among hospitalised tuberculosis patients in poor urban areas in Manila, The Philippines


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Title: Risk factors for death among hospitalised tuberculosis patients in poor urban areas in Manila, The Philippines
Other Titles: フィリピンマニラ貧困地区の病院に入院した結核患者の死亡危険因子に関する研究
Authors: 島崎, 貴治
Authors (alternative): Shimazaki, Takaharu
Issue Date: 20-Mar-2015
Publisher: The Union
Citation: Nagasaki University (長崎大学), 博士(医学) (2015-03-20)
Abstract: OBJECTIVE: To determine the mortality rate and risk factors for in-hospital death among hospitalised human immunodeficiency virus (HIV) negative tuberculosis (TB) patients in poor urban areas in the Philippines. DESIGN: A cross-sectional study was conducted at a national infectious disease hospital in Manila City. The target population was patients aged ≥13 years with all forms of HIV-negative TB admitted from October to December 2009. Demographic and clinical information was collected from medical charts, and risk of in-hospital death was measured. RESULTS: Of 407 HIV-negative TB patients, four were excluded due to missing records, and 403 were included in the analysis. The majority were poor urban residents (90%), and 66% were males. Overall, 37.5% of hospitalised patients died in the hospital (151/403), 30% of whom died before the third day of hospitalisation. Risk factor analysis demonstrated that complications of bacterial pneumonia had the greatest effect on in-hospital death (aOR 4.53, 95%CI 2.65–7.72), followed by anorexia (aOR 3.01, 95%CI 1.55–5.84), anaemia (haemoglobin <10 g/dl, aOR 2.35, 95%CI 1.34–4.13) and older age (aged ≥50 years, aOR 1.85, 95%CI 1.08–3.17). The presence of haemoptysis (aOR 0.44, 95%CI 0.25–0.80) was associated with improved survival. CONCLUSION: Mortality among hospitalised HIV-negative TB patients was extremely high in poor urban areas in the Philippines.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第776号 学位授与年月日:平成27年3月20日 / Author: Takaharu Shimazaki, Shane D. Marte, Naomi Ruth D. Saludar, Efren M. Dimaano, Eumelia P. Salva, Koya Ariyoshi, Jose B. Villarama, Motoi Suzuki / Citation: The International Journal of Tuberculosis and Lung Disease, 17(11), pp.1420-1426; 2013
Keywords: high-burden country / in-hospital death / urban poverty
URI: http://hdl.handle.net/10069/36104
ISSN: 10273719
DOI: 10.5588/ijtld.12.0848
Relational Links: http://hdl.handle.net/10069/35654
Rights: Reprinted with permission of the International Union Against Tuberculosis and Lung Disease. Copyright © The Union.
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/36104

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