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Relationships Between Clinical Characteristics and Decreased Plakoglobin and Connexin 43 Expressions in Myocardial Biopsies From Patients With Arrhythmogenic Right Ventricular Cardiomyopathy


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Title: Relationships Between Clinical Characteristics and Decreased Plakoglobin and Connexin 43 Expressions in Myocardial Biopsies From Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Yoshida, Takeo / Kawano, Hiroaki / Kusumoto, Saburo / Fukae, Satoki / Koga, Seiji / Ikeda, Satoshi / Koide, Yuji / Abe, Kuniko / Hayashi, Tomayoshi / Maemura, Koji
Issue Date: 2-Dec-2015
Publisher: インターナショナル・ハート・ジャーナル刊行会 / International Heart Journal Association
Citation: International Heart Journal, 56(6), pp.626-631; 2015
Abstract: Reduced expressions of plakoglobin and connexin 43 have been reported in the myocardium of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). However, the relationships between these expression abnormalities and the clinical features of ARVC remain unknown. The expressions of plakoglobin and connexin 43 in myocardial biopsy specimens from 10 patients with confirmed ARVC, and 13 control patients without ARVC (non-ARVC; hypertrophic cardiomyopathy, n = 7; dilated cardiomyopathy, n = 6), were examined by immunostaining to evaluate the relationships between these expressions and the clinical characteristics of ARVC. The ratios of plakoglobin/N-cadherin and of plakoglobin/connexin 43 expressions were significantly lower in the ARVC group than in the control group. Significantly more patients had decreased plakoglobin expression in the ARVC group than in the control group (9/10 versus 7/13; P = 0.0376). Sustained ventricular tachycardia occurred more frequently in patients with ARVC and with decreased expressions of both plakoglobin and connexin 43 than in those with decreased expression of plakoglobin alone (5/5 versus 1/4, P = 0.048). Decreased expressions of both connexin 43 and plakoglobin in the myocardium might be associated with the development of arrhythmia in ARVC.
Keywords: Arrhythmia / Intercalated disc / Pathology
URI: http://hdl.handle.net/10069/36126
ISSN: 13492365
DOI: 10.1536/ihj.15-144
Rights: © 2015 by the International Heart Journal Association
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/36126

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