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The Association of Cytokines with Severe Dengue in Children


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Title: The Association of Cytokines with Severe Dengue in Children
Authors: Mangione, Julia N.A. / Huy, Nguyen Tien / Lan, Nguyen Thi Phuong / Mbanefo, Evaristus Chibunna / Ha, Tran Thi Ngoc / Bao, Lam Quoc / Nga, Cao Thi Phi / Tuong, Vo Van / Dat, Tran Van / Thuy, Tran Thi / Tuan, Ha Manh / Huong, Vu Thi Que / Hirayama, Kenji
Issue Date: 30-Oct-2014
Publisher: 日本熱帯医学会 / Japanese Society of Tropical Medicine
Citation: Tropical Medicine and Health, 42(4), pp.137-144; 2014
Abstract: Background: Dengue virus infection is a major public health problem. A hypothesis put forward for severe dengue is the cytokine storm, a sudden increase in cytokines that induces vascular permeability. Previous studies and our recent meta-analysis showed that IL-6, IL-8, IFNγ, TNFα, VEGF-A and VCAM-1 are associated with dengue shock syndrome. Therefore, in this study we aim to validate the association of these cytokines with severe dengue. Methods & Findings: In a hospital based-case control study in Vietnam, children with dengue fever, other febrile illness and healthy controls were recruited. Dengue virus infection was confirmed by several diagnostic tests. Multiplex immunoassay using Luminex technology was used to measure cytokines simultaneously. A positive association with dengue shock syndrome was found for VCAM-1, whereas a negative association was found for IFNγ. Furthermore, multivariate logistic analysis also showed that VCAM-1 and IFNγ were independently correlated with dengue shock syndrome. Conclusion: IFNγ and VCAM-1 were associated with dengue shock syndrome, although their role in the severe dengue pathogenesis remains unclear. Additional studies are required to shed further light on the function of these cytokines in severe dengue.
Keywords: Association / Cytokine / Dengue / Severity
URI: http://hdl.handle.net/10069/36131
ISSN: 13488945
DOI: 10.2149/tmh.2014-09
Rights: © 2014 Japanese Society of Tropical Medicine
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/36131

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