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Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population


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Title: Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population
Authors: Migita, Kiyoshi / Jiuchi, Yuka / Furukawa, Hiroshi / Nakamura, Minoru / Komori, Atsumasa / Yasunami, Michio / Kozuru, Hideko / Abiru, Seigo / Yamasaki, Kazumi / Nagaoka, Shinya / Hashimoto, Satoru / Bekki, Shigemune / Yoshizawa, Kaname / Shimada, Masaaki / Kouno, Hiroshi / Kamitsukasa, Hiroshi / Komatsu, Tatsuji / Hijioka, Taizo / Nakamuta, Makoto / Naganuma, Atsushi / Yamashita, Haruhiro / Nishimura, Hideo / Ohta, Hajime / Nakamura, Yoko / Ario, Keisuke / Oohara, Yukio / Sugi, Kazuhiro / Tomizawa, Minoru / Sato, Takeaki / Takahashi, Hironao / Muro, Toyokichi / Makita, Fujio / Mita, Eiji / Sakai, Hironori / Yatsuhashi, Hiroshi
Issue Date: 12-Dec-2015
Publisher: BioMed Central
Citation: BMC Research Notes, 8, 777; 2015
Abstract: Background: Previous genome-wide association studies have evaluated the impact of common genetic variants and identified several non-HLA risk loci associated with autoimmune liver diseases. More recent genome-wide association studies and replication analyses reported an association between variants of the CARD10 polymorphism rs6000782 and risk of type 1 autoimmune hepatitis (AIH). In this case-control study, we genotyped 326 Japanese AIH patients and 214 control subjects. Results: Genomic DNA from 540 individuals of Japanese origin, including 326 patients with type-1 AIH and 214 healthy controls, was analyzed for two single nucleotide polymorphisms (SNPs) in the CARD10 gene. We selected CARD10 rs6000782 SNPs and genotyped these using PCR-RFLP method and direct sequencing. The Chi square test revealed that the rs6000782 variant alle (c) was not associated with the susceptibility for AIH in a Japanese population [p = 0.376, odds ratio (OR) 1.271, 95 % confidence interval (CI) 0.747-2.161] in an allele model. Our data also showed that CARD10 rs6000782 variants were not associated with AIH or with the clinical parameters of AIH. Conclusions: In this study we examined an association between rs6000782 SNPs in the CARD10 gene and type-1 AIH. Results showed no significant association of rs62000782 with type-1 AIH in a Japanese population. This study demonstrated no association between CARD10 rs6000782 variants and AIH in a Japanese population.
Keywords: Autoimmune hepatitis / CARD10 / Genetic factor / Genome-wide association study
URI: http://hdl.handle.net/10069/36132
DOI: 10.1186/s13104-015-1733-4
Rights: © 2015 Migita et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/36132

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