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Down-Regulation of Nogo-B Expression as a Newly Identified Feature of Intrahepatic Cholangiocarcinoma


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Title: Down-Regulation of Nogo-B Expression as a Newly Identified Feature of Intrahepatic Cholangiocarcinoma
Authors: Nanashima, Atsushi / Hatachi, Go / Tominaga, Tetsurou / Murakami, Goushi / Takagi, Katsunori / Arai, Junichi / Wada, Hideo / Nagayasu, Takeshi / Sumida, Yorihisa
Issue Date: 9-Dec-2015
Publisher: 東北ジャーナル刊行会 / Tohoku University Medical Press
Citation: The Tohoku Journal of Experimental Medicine, 238(1), pp.9-16; 2016
Abstract: Nogo-B, located in the endoplasmic reticulum, is an isoform belonging to the reticulon protein family, which is expressed specifically in cholangiocytes and non-parenchymal cells in the liver. Nogo-B expression is down-regulated with the progression of liver fibrosis, but its distinct function in liver malignancies has not been fully clarified. We have hypothesized that Nogo-B expression may be altered in intrahepatic cholangiocarcinoma (ICC), a relatively rare type of primary liver cancer with highly malignant behavior. The present study aimed to investigate the relationship between Nogo-B expression, assessed by immunohistochemical staining, and clinicopathological factors and prognosis in 34 ICC patients. Positive expression was observed in 19 (56%) of 34 ICC specimens: 6 patients (18%) with positivity levels of 1+ (positive cells in 10-50% of cancer cells) and 13 patients (38%) with 2+ (positive cells over 50%). Importantly, the remaining 15 patients (44%) were categorized as negative expression (Nogo-B-positive cells, less than 10%). Conversely, the mass-forming type of ICC tended to express Nogo-B with the degree of 2+ positivity, compared to the periductal infiltration type (p = 0.064), and the mass-forming type showed a better 5-year survival rate (66% vs. 5%) after hepatectomy (p < 0.05). However, the degree of positivity was not associated with tumor relapse rate, disease-free and overall survival, although each of the periductal infiltration type, intrahepatic metastasis, larger tumor size, and lower microvessel counts was associated with lower survival rates. We propose that Nogo-B expression is down-regulated in ICC, the implication of which, however, remains to be investigated.
Keywords: Cholangiole proliferation / Hepatic resection / Intrahepatic cholangiocarcinoma / Macroscopic finding / Nogo-B
URI: http://hdl.handle.net/10069/36135
ISSN: 00408727
DOI: 10.1620/tjem.238.9
Rights: © 2016 Tohoku University Medical Press
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/36135

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