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Increased levels of cell-free miR-517a and decreased levels of cell-free miR-518b in maternal plasma samples from placenta previa pregnancies at 32 weeks gestation


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Title: Increased levels of cell-free miR-517a and decreased levels of cell-free miR-518b in maternal plasma samples from placenta previa pregnancies at 32 weeks gestation
Other Titles: 前置胎盤合併妊婦では妊娠32週における母体血漿中miR-517aは増加し、miR-518bは減少する
Authors: 長谷川, ゆり
Authors (alternative): Hasegawa, Yuri
Issue Date: 3-Feb-2016
Publisher: Sage
Citation: Nagasaki University (長崎大学), 博士(医学) (2016-02-03)
Abstract: Objective: The aim of this study was to clarify the association between placenta previa and circulating levels of cell-free pregnancy-associated placenta-specific microRNAs (miRNAs) in maternal plasma. Method: Twenty singleton pregnancies with placenta previa (placenta previa group) and 26 uncomplicated pregnancies (control group) were recruited. Blood sampling was performed at 32 weeks of gestation, and cesarean delivery in all cases of placenta previa was performed at a mean gestational age of 37 weeks. The maternal plasma concentrations of cell-free pregnancy-associated placenta-specific miRNAs (miR-517a and miR-518b) were measured by absolute quantitative real-time reverse transcription-polymerase chain reaction. Results: Plasma concentrations of cell-free miR-517a were significantly higher in the placenta previa group than that in the control group (P = .011), while the plasma concentration of cell-free miR-518b was significantly lower in the placenta previa group than that in the control group (P = .004). Plasma concentrations of cell-free miR-517a in placenta previa were significantly higher in placenta previa with alert bleeding later group than those in placenta previa without alert bleeding group or control group (P = .030 or .047, respectively) and correlated with the volume of hemorrhage at delivery (R and P value: .512 and .025). Conclusion: Plasma concentrations of cell-free miR-517a and miR-518b at 32 weeks of gestation were altered in pregnant women with placenta previa, and the circulating level of cell- free miR-517a in placenta previa may be a predictive marker for the risks of alert bleeding later and massive hemorrhage at delivery.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)乙第42号 学位授与年月日:平成28年2月3日 / Author: Yuri Hasegawa, Kiyonori Miura, Ai Higashijima, Shuhei Abe, Shoko Miura, Koh-ichiro Yoshiura, Hideaki Masuzaki / Citation: Reproductive Sciences, 22(12), pp.1569-1576; 2015
Keywords: pregnancy-associated microRNA / maternal plasma / placenta previa / alert bleeding / hemorrhage
URI: http://hdl.handle.net/10069/36213
ISSN: 1933-7191
DOI: 10.1177/1933719115589407
Rights: (C)2015, Society for Reproductive Investigation. / The final, definitive version of this paper has been published in Reproductive Sciences, Vol.22(12), December 2015 by SAGE Publications Ltd, All rights reserved.
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/36213

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