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Uptake of Aortic 18F-FDG Is Correlated with Low-Density Lipoprotein Cholesterol and Leptin in a General Population


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Title: Uptake of Aortic 18F-FDG Is Correlated with Low-Density Lipoprotein Cholesterol and Leptin in a General Population
Other Titles: 一般住民における大動脈のFDG集積はLDLコレステロール及びレプチンと関連する
Authors: 原口, 愛
Authors (alternative): Haraguchi, Ai
Issue Date: 18-Mar-2016
Publisher: Public Library of Science
Citation: Nagasaki University (長崎大学), 博士(医学) (2016-03-18)
Abstract: Objective: This study investigated the relationship between aortic 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and clinical and laboratory findings related to atherosclerosis in a general population. Methods: 18F-FDG uptake in the ascending aorta was measured on the positron emission tomography/computed tomography (PET/CT) scans of 211 Japanese adults. The maximum target-to-background ratio (TBR) was compared with clinical and laboratory atherosclerosis findings. Results: By multivariate regression analysis adjusted for age and sex, TBR-ascending aorta (TBR-A) was significantly correlated with various clinical and laboratory parameters, such as body mass index, log visceral fat area, low-density lipoprotein cholesterol (LDL-C), log fasting immunoreactive insulin, log homeostasis model assessment of insulin resistance, log total adiponectin and log-leptin, in all subjects. Furthermore, by multivariate linear regression analysis adjusted for confounding factors, TBR-A was significantly correlated with LDL-C (b = 0.001, p = 0.03) and log-leptin (b = 0.336, p,0.01) in all subjects. Conclusion: TBR-A was significantly correlated with LDL-C and log-leptin independent from confounding factors. Our results suggest that aortic 18F-FDG uptake is a good marker of atherosclerosis, even in a general population.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第831号 学位授与年月日:平成28年3月18日 / Author: Ai Haraguchi, Naomi Hayashida, Toshihiko Kamasaki, Izumi Miyamoto, Toshiya Usui, Takao Ando, Norio Abiru, Hironori Yamasaki, Kenya Chiba, Takashi Kudo, Atsushi Kawakami, Noboru Takamura / Citation: PLoS ONE, 9(11), e111990; 2014
URI: http://hdl.handle.net/10069/36268
DOI: 10.1371/journal.pone.0111990
Relational Links: http://hdl.handle.net/10069/36499
Rights: (C) 2014 Haraguchi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/36268

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