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A New Strategy for Surgical Intervention of Bisphosphonate-Related Osteonecrosis of the Jaw : A retrospective study.


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Title: A New Strategy for Surgical Intervention of Bisphosphonate-Related Osteonecrosis of the Jaw : A retrospective study.
Authors: Yamada, Shin-ichi / Hayashida, Saki / Yanamoto, Souichi / Naruse, Tomofumi / Matsusita, Yuki / Uda, Akiko / Rokutanda, Satoshi / Kakehashi, Hiroe / Ikeda, Hisazumi / Asahina, Izumi / Umeda, Masahiro
Issue Date: Apr-2016
Publisher: Nagasaki University School of Medicine / 長崎大学医学部
Citation: Acta medica Nagasakiensia, 60(3), pp.97-102; 2016
Abstract: Bisphosphonates (BPs) are now widely used to treat various skeletal complications. Although the number of reported cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is rapidly increasing worldwide, therapeutic strategies remain controversial. Conservative treatments including antibacterial mouth rinses, the systemic administration of antibiotics, and superficial debridement in stage II BRONJ have been recommended by the American Association of Oral and Maxillofacial Surgeons position paper. However, these treatments are only partially successful. We performed a surgical intervention that consisted of osteotomy and primary wound closure in patients with stages II and III BRONJ. Forty-three out of 44 cases were treated effectively by this strategy, leading to improvements in quality of life. All BRONJ patients treated with oral BPs were treated successfully by the surgical intervention. We also proposed a surgical intervention for patients with stage II BRONJ.
Keywords: bisphosphonate-related osteonecrosis of jaws (BRONJ) / surgical intervention / bisphosphonate / conservative treatment
URI: http://hdl.handle.net/10069/36571
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 60, No. 3

Citable URI : http://hdl.handle.net/10069/36571

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