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Clinical Characteristics of Patients with Gastroesophageal Reflux Disease Refractory to Proton Pump Inhibitors and the Effects of Switching to 20 mg Esomeprazole on Reflux Symptoms and Quality of Life


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Title: Clinical Characteristics of Patients with Gastroesophageal Reflux Disease Refractory to Proton Pump Inhibitors and the Effects of Switching to 20 mg Esomeprazole on Reflux Symptoms and Quality of Life
Authors: Takeshima, Fuminao / Hashiguchi, Keiichi / Onitsuka, Yasunori / Tanigawa, Ken / Minami, Hitomi / Matsushima, Kayoko / Akazawa, Yuko / Shiozawa, Ken / Yamaguchi, Naoyuki / Taura, Naota / Ohnita, Ken / Ichikawa, Tatsuki / Isomoto, Hajime / Nakao, Kazuhiko
Issue Date: 31-Dec-2015
Publisher: International Scientific Literature Inc.
Citation: Medical Science Monitor, 21, pp.4111-4121; 2015
Abstract: Background: Refractory gastroesophageal reflux disease (GERD) may deteriorate patient quality of life (QOL) despite proton pump inhibitor (PPI) therapy. Material/Methods: Nineteen Japanese institutions were surveyed to determine the clinical characteristics and QOL of patients with refractory GERD. Those patients treated with a conventional PPI were switched to 20 mg esomeprazole for 4 weeks. Symptoms and QOL were assessed using Global Overall Symptom and Gastrointestinal Symptom Rating Scale (GSRS) questionnaires at baseline and at 2 and/or 4 weeks of esomeprazole treatment. Results: Of 120 patients who completed the survey, 58 (48.3%) had refractory GERD. Of these, 69.0% were aged >65 years, 79.3% were prescribed a PPI at a standard or high dose, and 22.4% were prescribed a PPI together with another drug. After switching to esomeprazole, patients reported significant improvements in heartburn, acid regurgitation, and excessive belching at 2 weeks using a symptom diary, as well as the total score, reflux, ab dominal pain, and indigestion, which were assessed using the GSRS at 4 weeks. Conclusions: About half of Japanese patients with GERD may be refractory to conventional PPIs. Their reflux-related symp toms are often severe and may impair QOL. Switching to esomeprazole could be used to improve their symptoms and QOL.
Keywords: Esomeprazole / Gastroesophageal Reflux / Proton Pump Inhibitors / Quality of Life
URI: http://hdl.handle.net/10069/36910
DOI: 10.12659/MSM.895346
Rights: © Med Sci Monit, 2015 / This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/36910

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