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The First Case of Deceased Donor Liver Transplantation for a Patient with End-Stage Liver Cirrhosis Due to Human Immunodeficiency Virus and Hepatitis C Virus Coinfection in Japan


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Title: The First Case of Deceased Donor Liver Transplantation for a Patient with End-Stage Liver Cirrhosis Due to Human Immunodeficiency Virus and Hepatitis C Virus Coinfection in Japan
Authors: Eguchi, Susumu / Takatsuki, Mitsuhisa / Soyama, Akihiko / Hidaka, Masaaki / Kugiyama, Tota / Natsuda, Koji / Adachi, Tomohiko / Kitasato, Amane / Fujita, Fumihiko / Kuroki, Tamotsu
Issue Date: 21-Jan-2016
Publisher: 国立感染症研究所 / National Institute of Infectious Diseases
Citation: Japanese Journal of Infectious Diseases, 69(1), pp.80-82; 2016
Abstract: We previously reported that progression of liver cirrhosis is quicker and survival is dismal in patients with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection, especially when acquired in childhood through contaminated blood products. Recently, we performed the first deceased donor liver transplantation (DDLT) for an HIV/HCV-coinfected hemophilic patient in Japan. A 40-year-old man was referred to our hospital for liver transplantation. Regular DDLT was performed using the piggyback technique with a full-sized liver graft. Cold ischemia time was 465 min, and the graft liver weighed 1,590 g. The antiretroviral therapy (ART) was switched from darunavir/ritonavir to raltegravir before the transplant for flexible usage of calcineurin inhibitors postoperatively; tenofovir was used as the baseline treatment. The postoperative course was uneventful, and the patient was discharged home on day 43. He started receiving anti-HCV treatment on day 110 with pegylated interferon, ribavirin, and simeprevir after the DDLT. Herein, we report the first case of DDLT in Japan. Meticulous management of ART and clotting factors could lead to the success of DDLT.
Keywords: human immunodeficiency virus / hepatitis C virus / liver transplantation / deceased donor / hemophilia
URI: http://hdl.handle.net/10069/36917
ISSN: 13446304
DOI: 10.7883/yoken.JJID.2015.121
Rights: © 2016 National Institute of Infectious Diseases
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/36917

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