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Recruitment of distinct immune cell populations to the lung after intratracheal TLR4 signaling activation by two different stimulations


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Title: Recruitment of distinct immune cell populations to the lung after intratracheal TLR4 signaling activation by two different stimulations
Other Titles: 異なる二種類の刺激による気管内Toll様受容体4(TLR4)シグナル伝達活性化に伴う、特徴的な免疫細胞集団の肺への遊走
Authors: 稲村, 幸雄
Authors (alternative): Inamura, Yukio
Issue Date: 8-Mar-2017
Publisher: 長崎大学医学部
Citation: Nagasaki University (長崎大学), 博士(医学) (2017-03-08)
Abstract: The toll-like receptor 4 (TLR4)-mediated immune response is considered as one of the triggers of acute respiratory distress syndrome. The agonistic monoclonal antibody UT12 specific for the TLR4/MD2 complex induces immune activation in a manner distinct from lipopolysaccharide (LPS). In order to compare the effects of this differential TLR4 signaling activation, we examined immune cell recruitment to the lung following intratracheal inoculation with UT12 and LPS in mice. The increase in pulmonary neutrophils was much higher after LPS treatment compared with UT12 treatment, while CD11bhiCD11+cells increased to similar levels following both treatments. These changes were MyD88-dependent and TRIF-independent. These differential effects on immune cell recruitment to the lung suggest distinct underlying mechanisms in response to TLR4 stimulation. These findings further indicate that TLR signaling can lead to different outcomes depending on the ligand and activation pathway, which may relate to the complex pathogenesis of inflammatory lung diseases.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第934号 学位授与年月日:平成29年3月8日 / Author: Yukio Inamura, Kiri Honma, Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Kenji Fukudome, Atsushi Nanashima, Takeshi Nagayasu, and Katsuyuki Yui / Citation: Acta Medica Nagasakiensia, 60(2), pp.77−84; 2016
Keywords: lung / TLR4 / neutrophils / dendritic cells
URI: http://hdl.handle.net/10069/37068
ISSN: 00016055
Relational Links: http://hdl.handle.net/10069/37392
Rights: (C) 2016 Nagasaki University School of Medicine
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/37068

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