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Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system


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Title: Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system
Other Titles: 脂肪滴はヒト肝細胞株におけるPorphyromonas gingivalisのオートファジー・リソソームシステムを介した排除機構に影響する
Authors: 財津, 有未
Authors (alternative): Zaitsu, Yumi
Issue Date: 21-Mar-2017
Publisher: Elsevier Masson
Citation: Nagasaki University (長崎大学), 博士(歯学) (2017-03-21)
Abstract: Recent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model for NAFLD, we found that lipid droplets increased the existence of P. gingivalis in the cells at an early phase of infection. Confocal microscopic analysis revealed that lipid droplets affected the formation of autolysosomes in infected cells. Thus, lipid droplets affect the elimination of P. gingivalis in HepG2 cells by altering the autophagy-lysosome system.
Description: 長崎大学学位論文 学位記番号:博(医歯薬)甲第916号 学位授与年月日:平成29年3月21日 / Author: Yumi Zaitsu, Mayumi Iwatake, Keiko Sato, Takayuki Tsukuba / Citation: Microbes and Infection, 18(9), pp.565-571;2016
Keywords: Porphyromonas gingivalis / Non-alcoholic fatty liver disease / Autophagy / Lysosome / HepG2 cells
URI: http://hdl.handle.net/10069/37090
ISSN: 12864579
DOI: 10.1016/j.micinf.2016.05.004
Rights: © 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Type: Thesis or Dissertation
Text Version: ETD
Appears in Collections:dissertation

Citable URI : http://hdl.handle.net/10069/37090

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