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Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading


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タイトル: Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading
その他のタイトル: 非荷重とその後の再荷重に伴うマウスヒラメ筋における熱ショック転写因子1依存性の遅筋型ミオシン重鎖の発現応答
著者: 横山, 真吾
著者(別表記) : Yokoyama, Shingo
発行日: 2016年 6月 1日
出版者: John Wiley & Sons Ltd
引用: Nagasaki University (長崎大学), 博士(医学) (2016-06-01)
抄録: Aim: The effects of heat shock transcription factor 1 (HSF1) deficiency on the fibre type composition and the expression level of nuclear factor of activated T cells (NFAT) family members (NFATc1, NFATc2, NFATc3 and NFATc4), phosphorylated glycogen synthase kinase 3α (p-GSK3α) and p-GSK3β, microRNA-208b (miR-208b), miR-499 and slow myosin heavy chain (MyHC) mRNAs (Myh7 and Myh7b) of antigravitational soleus muscle in response to unloading with or without reloading were investigated. Methods: HSF1-null and wild-type mice were subjected to continuous 2-week hindlimb suspension followed by 2- or 4-week ambulation recovery. Results: In wild-type mice, the relative population of slow type I fibres, the expression level of NFATc2, p-GSK3 (α and β), miR-208b, miR-499 and slow MyHC mRNAs (Myh7 and Myh7b) were all decreased with hindlimb suspension, but recovered after it. Significant interactions between train and time (the relative population of slow type I fibres; P = 0.01, the expression level of NFATc2; P = 0.001, p-GSKβ; P = 0.009, miR-208b; P = 0.002, miR-499; P = 0.04) suggested that these responses were suppressed in HSF1-null mice. Conclusion: HSF1 may be a molecule in the regulation of the expression of slow MyHC as well as miR-208b, miR-499, NFATc2 and p-GSK3 (α and β) in mouse soleus muscle.
記述: 長崎大学学位論文 学位記番号:博(医歯薬)甲第872号 学位授与年月日:平成28年6月1日 / Author: S. Yokoyama, Y. Ohno, T. Egawa, K. Yasuhara, A. Nakai, T. Sugiura, Y. Ohira, T. Yoshioka, M. Okita, T. Origuchi, K. Goto / Citation: Acta Physiologica, 217(4), pp.325–337; 2016
キーワード: glycogen synthase kinase 3 / heat shock transcription factor 1 / microRNA / myosin heavy chain / nuclear factor of activated T cells
URI: http://hdl.handle.net/10069/37170
DOI: 10.1111/apha.12692
関連リンク : http://hdl.handle.net/10069/36592
権利: © 2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd. / This is the accepted version of the following article: Acta Physiologica, 217(4), pp.325–337; 2016, which has been published in final form at http://dx.doi.org/10.1111/apha.12692
資料タイプ: Thesis or Dissertation
原稿種類: ETD
出現コレクション:110 学位論文

引用URI : http://hdl.handle.net/10069/37170

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