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Granular C3 Dermatosis

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Title: Granular C3 Dermatosis
Authors: Hashimoto, Takashi / Tsuruta, Daisuke / Yasukochi, Atsushi / Imanishi, Hisayoshi / Sekine, Hideharu / Fujita, Teizo / Wanibuchi, Hideki / Gi, Min / Kárpáti, Sarolta / Sitaru, Cassian / Zone, John J. / Endo, Daisuke / Abe, Shinichi / Nishino, Tomoya / Koji, Takehiko / Ishii, Norito
Issue Date: Sep-2016
Publisher: Medical Journals/Acta D-V
Citation: Acta Dermato Venereologica, 96(6), pp.748-753; 2016
Abstract: There has been no previous systematic study of bullous skin diseases with granular basement membrane zone deposition exclusively of C3. In this study we collected 20 such patients, none of whom showed cutaneous vasculitis histopathologically. Oral dapsone and topical steroids were effective. Various serological tests detected no autoantibodies or autoantigens. Direct immunofluorescence for various complement components revealed deposition only of C3 and C5–C9, indicating that no known complement pathways were involved. Studies of in situ hybridization and micro-dissection with quantitative RT-PCR revealed a slight reduction in expression of C3 in patient epidermis. These patients may represent a new disease entity, for which we propose the term “granular C3 dermatosis”. The mechanism for granular C3 deposition in these patients is unknown, but it is possible that the condition is caused by autoantibodies to skin or aberrant C3 expression in epidermal keratinocytes.
Keywords: Basement membrane zone / Bullous disease / C3 / Direct immunofluorescence / Granular
URI: http://hdl.handle.net/10069/37236
ISSN: 00015555
DOI: 10.2340/00015555-2379
Rights: © 2016 The Authors.This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. / © 2016 Acta Dermato-Venereologica.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37236

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