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Human antibody response to dengue virus: implications for dengue vaccine design


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Title: Human antibody response to dengue virus: implications for dengue vaccine design
Authors: Moi, Meng Ling / Takasaki, Tomohiko / Kurane, Ichiro
Issue Date: 14-Mar-2016
Publisher: 日本熱帯医学会 / Japanese Society of Tropical Medicine
Citation: Tropical Medicine and Health, 44, 1; 2016
Abstract: Dengue, a global health threat, is a leading cause of morbidity and mortality in most tropical and subtropical countries. Dengue can range from asymptomatic, relatively mild dengue fever to severe and life-threatening dengue hemorrhagic fever. Disease severity and outcome is largely associated with the host immune response. Several candidate vaccines in clinical trials appear promising as effective measures for dengue disease control. Vaccine development has been hampered by safety and efficacy issues, driven by a lack of understanding of the host immune response. This review focuses on recent research findings on the dengue host immune response, particularly in humans, and the relevance of these findings to challenges in vaccine development.
Keywords: Antibody-dependent enhancement / Dengue virus / Disease protection / FcgammaR-expressing cells / Vaccine
URI: http://hdl.handle.net/10069/37291
DOI: 10.1186/s41182-016-0004-y
Rights: © Moi et al 2016 / This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37291

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