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Relapsed Pulmonary Cryptococcosis during Tumor Necrosis Factor α Inhibitor Treatment

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Title: Relapsed Pulmonary Cryptococcosis during Tumor Necrosis Factor α Inhibitor Treatment
Authors: Takazono, Takahiro / Sawai, Toyomitsu / Tashiro, Masato / Saijo, Tomomi / Yamamoto, Kazuko / Imamura, Yoshifumi / Miyazaki, Taiga / Suyama, Naofumi / Izumikawa, Koichi / Kakeya, Hiroshi / Yanagihara, Katsunori / Mukae, Hiroshi / Kohno, Shigeru
Issue Date: 1-Oct-2016
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 55(19), pp.2877-2880; 2016
Abstract: A 35-year-old non-HIV patient developed pulmonary cryptococcosis after the initiation of infliximab. He recovered by fluconazole treatment and completed the therapy for a total of 6 months. However, he experienced a relapse 16 months later during retreatment with infliximab, revealing an interesting clinical course contradicting retreatment. This case also represents the first case of relapsed pulmonary cryptococcosis suspected during treatment with a biologic agent. Both of these aspects generated important clinical questions about the length of pulmonary cryptococcosis treatment and the necessity of introducing a second prophylaxis for such patients.
Keywords: Biological agents / Infliximab / Pulmonary cryptococcosis / Relapse / Tumor necrosis factor α inhibitor
URI: http://hdl.handle.net/10069/37294
ISSN: 09182918
DOI: 10.2169/internalmedicine.55.6969
Rights: © 2016 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37294

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