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Relationship between immune function recovery and infectious complications in patients following living donor liver transplantation


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Title: Relationship between immune function recovery and infectious complications in patients following living donor liver transplantation
Authors: Kobayashi, Shinichiro / Soyama, Akihiko / Takatsuki, Mitsuhisa / Hidaka, Masaaki / Adachi, Tomohiko / Kitasato, Amane / Kinoshita, Ayaka / Hara, Takanobu / Kanetaka, Kengo / Fujita, Fumihiko / Kuroki, Tamotsu / Eguchi, Susumu
Issue Date: Aug-2016
Publisher: 日本肝臓学会 / Japan Society of Hepatology
Citation: Hepatology Research, 46(9), pp.908-915; 2016
Abstract: Aim: The ImmuKnow (IK) assay enables the evaluation of peripheral blood CD4+ adenosine triphosphate activity to facilitate an objective assessment of the cellular immune function in immunosuppressed patients. However, it is unclear whether the IK assay is utilized during the acute postoperative periods following living donor liver transplantation (LDLT). Methods: The IK values of 43 LDLT recipients were measured during the month following LDLT to evaluate the relationship between the measured IK values and infectious events. Results: The IK values after LDLT were significantly increased compared with the IK values before LDLT (P < 0.01). During the month following transplantation, the rate of bacterial infection in the recipients with IK values of more than 225 ng/mL was significantly lower than that in the recipients with IK values of 225 ng/mL or less (42.1% vs 91.7%, respectively; P < 0.01). The rate of severe infections among the recipients who maintained IK values of more than 150 ng/mL was significantly lower than that among the recipients with IK values of 150 ng/mL or less during the month following transplantation (3.7% vs 56.3%, respectively; P < 0.01). Conclusion: The immune system of LDLT recipients dramatically improved following transplantation. The IK values of LDLT recipients were associated with the incidence of infectious events during the perioperative period after LDLT. Monitoring IK values was useful during both the acute and long-term postoperative periods.
Keywords: bacterial and fungal infection / ImmuKnow / immunosuppression / living donor liver transplantation
URI: http://hdl.handle.net/10069/37307
ISSN: 13866346
DOI: 10.1111/hepr.12635
Rights: © 2015 The Japan Society of Hepatology / This is the peer reviewed version of the following article: Hepatology Research, 46(9), pp.908-915; 2016, which has been published in final form at http://dx.doi.org/10.1111/hepr.12635 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37307

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