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Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature

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Title: Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature
Authors: Matsuda, Katsuya / Tateishi, Seiko / Akazawa, Yuko / Kinoshita, Akira / Yoshida, Shiko / Morisaki, Sachiko / Fukushima, Ai / Matsuwaki, Takahiro / Yoshiura, Koh-Ichiro / Nakashima, Masahiro
Issue Date: 22-Oct-2016
Publisher: BioMed Central Ltd.
Citation: Diagnostic Pathology, 11, 101; 2016
Abstract: Background: Mitotically active cellular fibroma (MACF) of the ovary, characterized by relatively high mitotic activity without severe atypia, represents a relatively new disease entity. MACF is categorized as a benign ovarian tumor. However, due to a limited number of case reports, its clinical and pathological features and optimum management remains largely undetermined. Herein, we report on a rare case of MACF that grew rapidly in size and was diagnosed on detailed pathological examination. Case presentation: A 44-year-old Japanese woman, who detected a myoma-like lesion 1-year earlier, was referred to our hospital when the follow-up examination demonstrated that the mass had increased in size. Magnetic resonance imaging revealed a T1 isointense and T2 hyperintense tumor (11 cm in diameter) in the right pelvic cavity. Laparoscopy confirmed the presence of a right ovarian tumor and laparoscopic right adnexectomy was performed. The tumor cells consisted of dense cellular proliferations of spindle fibroblast-like cells without significant cytological atypia. The mitotic activity index was estimated at >15 mitotic figures per 10 high-power fields. Reticulin staining and FOXL2 mutation analysis excluded the possibility of an adult granulosa cell tumor, and the patient was diagnosed with a MACF of the ovary. Conclusions: To the best of our knowledge, we are the first to report on a case of rapid growth of a MACF of the ovary during follow-up. When an increase in the size of a solid ovarian mass is detected, a MACF should be considered as a differential diagnosis.
Keywords: Case report / FOXL2 analysis / Mitotically active cellular fibroma / Preoperative diagnosis / Rapid growth
URI: http://hdl.handle.net/10069/37330
DOI: 10.1186/s13000-016-0554-7
Rights: © The Author(s). 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37330

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