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Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis


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タイトル: Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis
著者: Mi-ichi, Fumika / Yoshida, Hiroki / Hamano, Shinjiro
発行日: 2016年10月20日
出版者: Public Library of Science
引用: PLOS Pathogens, 12(10), e1005845; 2016
抄録: mebiasis is caused by Entamoeba histolytica infection and can produce a broad range of clinical signs, from asymptomatic cases to patients with obvious symptoms. The current epidemiological and clinical statuses of amebiasis make it a serious public health problem worldwide. The Entamoeba life cycle consists of the trophozoite, the causative agent for amebiasis, and the cyst, the form responsible for transmission. These two stages are connected by “encystation” and “excystation.” Hence, developing novel strategies to control encystation and excystation will potentially lead to new measures to block the transmission of amebiasis by interrupting the life cycle of the causative agent. Here, we highlight studies investigating encystation using inhibitory chemicals and categorize them based on the molecules inhibited. We also present a perspective on new strategies to prevent the transmission of amebiasis.
URI: http://hdl.handle.net/10069/37341
DOI: 10.1371/journal.ppat.1005845
権利: © 2016 Mi-ichi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/37341

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