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Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients


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タイトル: Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients
著者: Takatsuki, Hanae / Fuse, Takayuki / Nakagaki, Takehiro / Mori, Tsuyoshi / Mihara, Ban / Takao, Masaki / Iwasaki, Yasushi / Yoshida, Mari / Murayama, Shigeo / Atarashi, Ryuichiro / Nishida, Noriyuki / Satoh, Katsuya
発行日: 2016年10月
出版者: Elsevier B.V.
引用: EBioMedicine, 12, pp.150-155; 2016
抄録: Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study to determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy. Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 106/g from a 50% seeding dose in non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 106/g SD50 did not exist the infectivity.
キーワード: Creutzfeldt-Jakob disease / Non-neural tissue / Prion / Prion-seeding activity / SD50
URI: http://hdl.handle.net/10069/37342
ISSN: 23523964
DOI: 10.1016/j.ebiom.2016.08.033
権利: © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/37342

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