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Recurrent Streptococcus agalactiae Toxic Shock Syndrome Triggered by a Tumor Necrosis Factor-α Inhibitor


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Title: Recurrent Streptococcus agalactiae Toxic Shock Syndrome Triggered by a Tumor Necrosis Factor-α Inhibitor
Authors: Yoshida, Masataka / Takazono, Takahiro / Tashiro, Masato / Saijo, Tomomi / Morinaga, Yoshitomo / Yamamoto, Kazuko / Nakamura, Shigeki / Imamura, Yoshifumi / Miyazaki, Taiga / Sawai, Toyomitsu / Nishino, Tomoya / Izumikawa, Koichi / Yanagihara, Katsunori / Mukae, Hiroshi / Kohno, Shigeru
Issue Date: 1-Nov-2016
Publisher: 日本内科学会
Citation: Internal Medicine, 55(21), pp.3211-3214; 2016
Abstract: Streptococcal toxic shock syndrome caused by group B streptococcus (GBS) is a rare, but lethal disease. We experienced a 45-year-old woman with pustular psoriasis who developed toxic shock-like syndrome during infliximab treatment. Surprisingly, similar episodes recurred three times in one year with restarting of infliximab treatments. In the third episode, GBS were detected in blood, urine, and vaginal secretion cultures. These episodes of shock syndrome were possibly due to GBS. To the best of our knowledge, this is the first case report of recurrent streptococcal toxic shock syndrome possibly caused by GBS which was induced by anti-TNF-α inhibitor therapy. The restarting of biological agents in patients with a history of toxic shock syndrome should therefore be avoided as much as possible.
Keywords: Infliximab / Recurrent / Streptococcal toxic shock syndrome / Streptococcus agalactiae / Tumor necrosis factor-α inhibitor
URI: http://hdl.handle.net/10069/37347
ISSN: 09182918
DOI: 10.2169/internalmedicine.55.6787
Rights: © 2016 by The Japanese Society of Internal Medicine
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37347

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