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Height indicates hematopoietic capacity in elderly Japanese men


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Title: Height indicates hematopoietic capacity in elderly Japanese men
Authors: Shimizu, Yuji / Sato, Shimpei / Koyamatsu, Jun / Yamanashi, Hirotomo / Nagayoshi, Mako / Kadota, Koichiro / Maeda, Takahiro
Issue Date: 4-Oct-2016
Publisher: Impact Journals LLC
Citation: Aging, 8(10), pp.2407-2413; 2016
Abstract: Previously, we reported that height is an indicator of the capacity of vascular repair in elderly men, especially hypertensive men. On the other hand, hemoglobin could act as a possible biochemical index of hypertensioninduced vascular damage. However, no studies have clarified the correlation between height and hematopoietic activity. We conducted a cross-sectional study of 249 men aged 65-69 undergoing a general health check-up. Reticulocyte was used to evaluate hematopoietic activity. Because hemoglobin concentration should influence hematopoietic activity, analyses stratified by hemoglobin level were performed. Independent of known cardiovascular risk factors and other hematological parameters (white blood cell count), a significant positive correlation was seen between height and reticulocytes for total subjects and subjects with a high hemoglobin concentration (≥14.5 g/dL), but not in subjects with a low hemoglobin concentration (<14.5 g/dL). The standardized parameter estimates (β) were β=0.18, p=0.003 for total subjects, β=0.28, p=0.001 for subjects with a high hemoglobin concentration, and β=0.03, p=0.717 for subjects with low hemoglobin. Independently, height is significantly positively correlated with reticulocyte in elderly Japanese men, particularly in men with a high hemoglobin concentration. These results indicate that subjects with a short stature might have lower hematopoietic capacity than those with a high stature.
Keywords: Elderly men / Height / Hematopoiesis / Reticulocyte
URI: http://hdl.handle.net/10069/37355
DOI: 10.18632/aging.101061
Rights: © 2016 Impact Journals, LLC / This is an open access article under the terms of the Creative Commons Attribution License (CC BY).
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37355

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