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Fewer subsequent relapses and lower levels of IL-17 in Takayasu arteritis developed after the age of 40 years


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Title: Fewer subsequent relapses and lower levels of IL-17 in Takayasu arteritis developed after the age of 40 years
Authors: Fukui, Shoichi / Iwamoto, Naoki / Shimizu, Toshimasa / Umeda, Masataka / Nishino, Ayako / Koga, Tomohiro / Kawashiri, Shin-ya / Ichinose, Kunihiro / Hirai, Yasuko / Tamai, Mami / Nakamura, Hideki / Aramaki, Toshiyuki / Iwanaga, Nozomi / Izumi, Yasumori / Origuchi, Tomoki / Migita, Kiyoshi / Ueki, Yukitaka / Sato, Shuntaro / Kawakami, Atsushi
Issue Date: 13-Dec-2016
Publisher: BioMed Central Ltd.
Citation: Arthritis Research & Therapy, 18, 293; 2016
Abstract: Background: The clinical characteristics of Takayasu arteritis (TAK) developing in individuals older than 40years (TAK >40) are little-known. Method: We retrospectively analyzed 43 patients with TAK treated at three hospitals in Japan from April 2000 to March 2016. From medical records we collected baseline variables at diagnosis including clinical symptoms, laboratory data, and subsequent relapses. We compared these indices in the patients with TAK onset at >40years of age (TAK >40) to those with TAK onset ≤40years (TAK ≤40). Multiplex cytokine/chemokine bead assays were performed using preserved serum supernatants from 24 patients with TAK and 40 healthy donors. Results: Of the 43 patients, 20 had TAK >40; this group had significantly fewer instances of orthostatic hypotension (2 (10%) vs. 10 (43%), p=0.019), carotid bruit (7 (35%) vs. 16 (70%), p=0.034), and chest pain (0 (0%) vs. 6 (26%), p=0.023) compared to patients with TAK ≤40 (n=23). The initial prednisolone dose was significantly lower in TAK >40 (median 30mg vs. 40mg per day, p=0.024). Assessed by the log-rank test, the relapse-free survival rate after remission was significantly higher in the patients with TAK >40 (p=0.029). The interleukin 17 levels were significantly lower in patients with TAK >40 compared to patients with TAK ≤40 and healthy donors. Conclusion: Compared to TAK ≤40, TAK >40 could be treated by lower initial doses of prednisolone to achieve remission, and with fewer relapses. These differences might be due to the difference of T helper 17 (Th17) activity suggested by the cytokine profiles.
Keywords: Age / Chemokines / Cytokines / IL-17 / Relapse / Takayasu arteritis
URI: http://hdl.handle.net/10069/37362
DOI: 10.1186/s13075-016-1193-9
Rights: © The Author(s). 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37362

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