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3,3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones


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Title: 3,3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones
Authors: Mizuta, Satoshi / Otaki, Hiroki / Kitamura, Kanami / Nishi, Kodai / Watanabe, Ken / Makau, Juliann Nzembi / Hashimoto, Ryo / Usui, Toshiya / Chiba, Kenya
Issue Date: Dec-2016
Publisher: Royal Society of Chemistry
Citation: Organic Chemistry Frontiers, 3(12), pp.1661-1667; 2016
Abstract: We herein describe a method for synthetic routes to multi-functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones. This involves a tandem stereoselective functionalization of 3,3-dibromo-2-trifluoromethyl acrylic acid ethyl ester and intramolecular cyclization reaction to afford precursors for a Suzuki-Miyaura cross-coupling reaction with arylboronic acids.
URI: http://hdl.handle.net/10069/37368
DOI: 10.1039/C6QO00360E
Rights: © the Partner Organisations 2016.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37368

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