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Interstitial Lung Disease Induced by Pazopanib Treatment

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Title: Interstitial Lung Disease Induced by Pazopanib Treatment
Authors: Ide, Shotaro / Sakamoto, Noriho / Hara, Shintaro / Hara, Atsuko / Kakugawa, Tomoyuki / Nakamura, Yoichi / Futsuki, Yoji / Izumikawa, Koichi / Ishimatsu, Yuji / Yanagihara, Katsunori / Mukae, Hiroshi
Issue Date: 1-Jan-2017
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 56(1), pp.79-83; 2017
Abstract: Although pneumothorax has been reported to be a major pulmonary adverse event in patients treated with pazopanib, a multikinase inhibitor, drug-induced interstitial lung disease (DILD) has not been reported. A 74-year-old Japanese man who received pazopanib for the treatment of femoral leiomyosarcoma and lung metastasis presented with dyspnea and fatigue. He had mild interstitial pneumonia when pazopanib treatment was initiated. Chest computed tomography revealed progressive bilateral ground-glass opacity (GGO) and traction bronchiectasis. We diagnosed DILD due to pazopanib. The patient’s pazopanib treatment was interrupted and a steroid was administered. The symptoms and GGO were improved with treatment. Physicians should be aware of DILD due to pazopanib in patients with pre-existing interstitial lung disease.
Keywords: Drug-induced interstitial lung disease / Interstitial pneumonia / Molecular target drug / Pazopanib / Pneumonitis
URI: http://hdl.handle.net/10069/37379
ISSN: 09182918
DOI: 10.2169/internalmedicine.56.7380
Rights: © 2017 The Japanese Society of Internal Medicine
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37379

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