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Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki

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Title: Persistence of Neutralizing Antibody Against Dengue Virus 2 After 70 Years from Infection in Nagasaki
Authors: Ngwe Tun, Mya Myat / Muta, Yoshihito / Inoue, Shingo / Morita, Kouichi
Issue Date: 1-Aug-2016
Publisher: Mary Ann Liebert Inc.
Citation: BioResearch Open Access, 5(1), pp.188-191; 2016
Abstract: This study aimed to investigate the duration of humoral immune responses to dengue virus (DENV) infection in Japanese who experienced acute febrile illness with hemorrhagic manifestations 70 years ago, when an epidemic of dengue occurred in Nagasaki, Japan, from 1942 to 1944. A Japanese volunteer requested serological diagnosis of DENV infection in 2014 and donated blood sample to measure the antibody titer against DENV by antiflavi IgG indirect ELISA, focus reduction neutralization test, and plaque reduction neutralization test. The serum sample of the volunteer was positive in flavi IgG ELISA and it indicated primary infection. In the neutralization test, the highest neutralizing titer was ≥218 for DENV-2. We report here the existence of DENV-specific antibodies in the serum of a person after 70 years from infection. Published reports indicated that DENV-1 was responsible for the 1942-1944 outbreak in Nagasaki. However, our data suggested that DENV-2 also played a role in this Nagasaki dengue epidemic.
Keywords: dengue / Japan / neutralization antibody
URI: http://hdl.handle.net/10069/37382
ISSN: 21647860
DOI: 10.1089/biores.2016.0016
Rights: © Mya Myat Ngwe Tun et al. 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/37382

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