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Enzymatic oxidation of ellagitannin and a new ellagitannin metabolite from Camellia japonica leaves


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タイトル: Enzymatic oxidation of ellagitannin and a new ellagitannin metabolite from Camellia japonica leaves
著者: Tsujita, Takaaki / Matsuo, Yosuke / Saito, Yoshinori / Tanaka, Takashi
発行日: 2017年 2月 2日
出版者: Elsevier Ltd.
引用: Tetrahedron, 73(5), pp.500-507; 2017
抄録: Polyphenols in the leaves of Camellia japonica L. at different stages of growth were analyzed by HPLC. Pedunculagin [2,3; 4,6-bis-(S)-hexahydroxydiphenoyl-D-glucose] was the major polyphenol in the youngest leaves. The levels of this compound and (+)-catechin decreased as the leaves matured. The level of (−)-epicatechin did not change with leaf maturity. Enzymatic oxidation of pedunculagin was examined to investigate the mechanism of the decrease. Pedunculagin was not directly oxidized by treatment with oxidative enzymes. However, when (+)-catechin was added to the reaction mixture, the pyrogallol rings of the 4,6-hexahydroxydiphenoyl group was oxidatively cleaved to give 2H-2-oxo-pyran-6-carboxylic acid. The in vitro oxidation products were not detected in fresh leaves, but two pedunculagin oxidation products conjugated with flavan-3-ol were isolated. A new metabolite, camelliatannin I, was isolated and characterized by spectroscopic and density functional theory calculation of NMR chemical shifts.
キーワード: 2H-2-Oxo-pyran-6-carboxylic acid / Camellia japonica / Camelliatannin / Catechin / Ellagitannin / Oxidation
URI: http://hdl.handle.net/10069/37424
ISSN: 00404020
DOI: 10.1016/j.tet.2016.12.027
権利: © 2016 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: Journal Article
原稿種類: author
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/37424

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